Objective:To analyze the diagnostic value of fecal Fusobacterium nucleatum detection,fecal immunochemical test(FIT),and carbohydrate antigen 19-9(CA19-9)detection for colorectal cancer(CRC).Method:Atotal of 78 CRC pat...Objective:To analyze the diagnostic value of fecal Fusobacterium nucleatum detection,fecal immunochemical test(FIT),and carbohydrate antigen 19-9(CA19-9)detection for colorectal cancer(CRC).Method:Atotal of 78 CRC patients and 60 healthy individuals were enrolled in this study.Stool and blood samples were collected for the 3 diagnoses,and ROC curves were analyzed for diagnostic value.Result:The 3 diagnoses’positive detection rates in CRC samples were significantly higher than those of healthy samples(P<0.05).The combined CRC diagnoses showed significantly higher sensitivity as compared to individual fecal F.nucleatum detection(χ^(2)=6.495,P=0.011),FIT(χ^(2)=4.871,P=0.027),and serum CA19-9 detection(χ^(2)=7.371,P=0.007).The area under the ROC curve for fecal F.nucleatum detection was 0.63[95%confidence interval(CI)=1.124–6.238],with a sensitivity of 73.08%and specificity of 85.00%,whereas FIT was 0.65(95%CI=1.365–9.241),with a sensitivity of 51.28%and specificity of 96.67%,meanwhile,serum CA19-9 detection was 0.62(95%CI=1.517–12.342),with a sensitivity of 69.23%and specificity of 98.33%.The combined CRC diagnoses showed an area under the ROC curve of 0.76(95%CI=1.213–6.254),with a sensitivity of 87.18%and specificity of 70.00%.Conclusion:The combined diagnoses of fecal F.nucleatum detection,FIT,and serum CA19-9 detection can significantly improve the sensitivity and accuracy of CRC diagnosis,which has high clinical application value to provide guidance for clinical CRC screening and early intervention treatment.展开更多
The </span><i><span style="font-family:Verdana;">Helicobacter pylori</span></i><span style="font-family:Verdana;"> (Hp) infection is a public health problem, esp...The </span><i><span style="font-family:Verdana;">Helicobacter pylori</span></i><span style="font-family:Verdana;"> (Hp) infection is a public health problem, especially in develo</span><span><span style="font-family:Verdana;">ping countries. However, the responsibility of Hp for the occurrence of recurrent abdominal pain is still unclear. </span><b><span style="font-family:Verdana;">Objectives</span></b><span style="font-family:Verdana;">: To determine the prevalence of </span><i><span style="font-family:Verdana;">Helicobacter pylori</span></i><span> </span><span style="font-family:Verdana;">(Hp) infection in children with recurrent abdominal pain (RAP) in Brazzaville and to establish the relations</span></span><span style="font-family:Verdana;">hip between Hp infection and RAP. </span><b><span style="font-family:Verdana;">Patients</span></b> <b><span style="font-family:Verdana;">and</span></b> <b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> We conducted a cross-sectional case-control study, between March and September 2018, including 106 children with RAP and 218 children without RAP, aged 2 to 17 years old, received in health centres in Brazzaville. All the children were sub</span><span style="font-family:Verdana;">jected to detection of Hp fecal antigen by qualitative immuno-chromatography</span><span style="font-family:Verdana;"> in the faeces. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> The prevalence of Hp infection among children with RAP in Brazzaville was 43.4%. The female sex was most represented in both populations, with a sex ratio of 0.84 in the infected population. Compared with controls, these were children with a mean age of 8.13 ± 4.57 years. Infected children with RAP were unschooled in 66.7% (n = 31) of cases (p < 0.05). Those using potty were 63% (n = 29). Handwashing before meals and after using the toilet was not done in 66.7% (n = 31) and 56.5% (n = 26) of cases, respectively. The proportio展开更多
基金The In-Hospital Fund of the Affiliated Hospital of Hebei University(2017Q004)the Medical Research Project of Hebei Provincial Health Commission(20190924)。
文摘Objective:To analyze the diagnostic value of fecal Fusobacterium nucleatum detection,fecal immunochemical test(FIT),and carbohydrate antigen 19-9(CA19-9)detection for colorectal cancer(CRC).Method:Atotal of 78 CRC patients and 60 healthy individuals were enrolled in this study.Stool and blood samples were collected for the 3 diagnoses,and ROC curves were analyzed for diagnostic value.Result:The 3 diagnoses’positive detection rates in CRC samples were significantly higher than those of healthy samples(P<0.05).The combined CRC diagnoses showed significantly higher sensitivity as compared to individual fecal F.nucleatum detection(χ^(2)=6.495,P=0.011),FIT(χ^(2)=4.871,P=0.027),and serum CA19-9 detection(χ^(2)=7.371,P=0.007).The area under the ROC curve for fecal F.nucleatum detection was 0.63[95%confidence interval(CI)=1.124–6.238],with a sensitivity of 73.08%and specificity of 85.00%,whereas FIT was 0.65(95%CI=1.365–9.241),with a sensitivity of 51.28%and specificity of 96.67%,meanwhile,serum CA19-9 detection was 0.62(95%CI=1.517–12.342),with a sensitivity of 69.23%and specificity of 98.33%.The combined CRC diagnoses showed an area under the ROC curve of 0.76(95%CI=1.213–6.254),with a sensitivity of 87.18%and specificity of 70.00%.Conclusion:The combined diagnoses of fecal F.nucleatum detection,FIT,and serum CA19-9 detection can significantly improve the sensitivity and accuracy of CRC diagnosis,which has high clinical application value to provide guidance for clinical CRC screening and early intervention treatment.
文摘The </span><i><span style="font-family:Verdana;">Helicobacter pylori</span></i><span style="font-family:Verdana;"> (Hp) infection is a public health problem, especially in develo</span><span><span style="font-family:Verdana;">ping countries. However, the responsibility of Hp for the occurrence of recurrent abdominal pain is still unclear. </span><b><span style="font-family:Verdana;">Objectives</span></b><span style="font-family:Verdana;">: To determine the prevalence of </span><i><span style="font-family:Verdana;">Helicobacter pylori</span></i><span> </span><span style="font-family:Verdana;">(Hp) infection in children with recurrent abdominal pain (RAP) in Brazzaville and to establish the relations</span></span><span style="font-family:Verdana;">hip between Hp infection and RAP. </span><b><span style="font-family:Verdana;">Patients</span></b> <b><span style="font-family:Verdana;">and</span></b> <b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> We conducted a cross-sectional case-control study, between March and September 2018, including 106 children with RAP and 218 children without RAP, aged 2 to 17 years old, received in health centres in Brazzaville. All the children were sub</span><span style="font-family:Verdana;">jected to detection of Hp fecal antigen by qualitative immuno-chromatography</span><span style="font-family:Verdana;"> in the faeces. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> The prevalence of Hp infection among children with RAP in Brazzaville was 43.4%. The female sex was most represented in both populations, with a sex ratio of 0.84 in the infected population. Compared with controls, these were children with a mean age of 8.13 ± 4.57 years. Infected children with RAP were unschooled in 66.7% (n = 31) of cases (p < 0.05). Those using potty were 63% (n = 29). Handwashing before meals and after using the toilet was not done in 66.7% (n = 31) and 56.5% (n = 26) of cases, respectively. The proportio
