Chronic infammation and nutritional imbalance are impor-tant comorbid conditions that correlate with poor clinical outcomes in children with chronic kidney disease （CKD）. Nutritional disorders such as cachexia/prote...Chronic infammation and nutritional imbalance are impor-tant comorbid conditions that correlate with poor clinical outcomes in children with chronic kidney disease （CKD）. Nutritional disorders such as cachexia/protein energy wasting, obesity and growth retardation negatively impact the quality of life and disease progression in children with CKD. Inadequate nutrition has been asso-ciated with growth disturbances in children with CKD. On the other hand, over-nutrition and obesity are associated with poor outcomes in children with CKD. The exact mechanisms leading to these unfavorable conditions are not fully elucidated and are most likely multifactorial. In this review, we focus on the pathophysiology of nutrition disorders and infammation and their impact on clinical outcomes in children with CKD.展开更多
基金Supported by The Capital Health Research and Development of Special Research Fund 2014-4-2102(to Juan Tu)
文摘Chronic infammation and nutritional imbalance are impor-tant comorbid conditions that correlate with poor clinical outcomes in children with chronic kidney disease （CKD）. Nutritional disorders such as cachexia/protein energy wasting, obesity and growth retardation negatively impact the quality of life and disease progression in children with CKD. Inadequate nutrition has been asso-ciated with growth disturbances in children with CKD. On the other hand, over-nutrition and obesity are associated with poor outcomes in children with CKD. The exact mechanisms leading to these unfavorable conditions are not fully elucidated and are most likely multifactorial. In this review, we focus on the pathophysiology of nutrition disorders and infammation and their impact on clinical outcomes in children with CKD.
