目的分析探讨头颈部恶性肿瘤(head and neck cancer,HNC)患者放射治疗(放疗)结束时的营养不良状况与营养相关症状和生活质量的关系。方法通过便利抽样法选择2018年12月至2020年1月于北京某肿瘤医院放疗科门诊头颈组完成放疗的HNC患者为...目的分析探讨头颈部恶性肿瘤(head and neck cancer,HNC)患者放射治疗(放疗)结束时的营养不良状况与营养相关症状和生活质量的关系。方法通过便利抽样法选择2018年12月至2020年1月于北京某肿瘤医院放疗科门诊头颈组完成放疗的HNC患者为横断面研究对象。采用以下3种标准进行营养不良评定:体重指数(body mass index,BMI)<18.5 kg/m^2伴一般情况差(简称BMI标准);营养风险筛查2002评分(nutritional risking screening 2002,NRS 2002)营养状态受损评分为3分(简称NRS 2002标准);全球(营养)领导人诊断营养不良标准(global leadership initiative on malnutrition,GLIM)但不包括肌肉量测定(简称GLIM标准),并根据GLIM标准将患者分为营养不良与营养正常两组。采用头颈部患者症状调查表调查营养相关症状情况。采用欧洲癌症研究与治疗组织生活质量核心评定量表调查生活质量。结果共210例HNC患者纳入分析,根据BMI标准,19例(9.0%)患者存在营养不良;根据NRS 2002标准,110例(52.4%)患者存在营养不良;根据GLIM标准,145例(69.0%)患者存在营养不良。发生率>80.0%的营养相关症状有疼痛、口干、唾液黏稠和味觉改变,对进食干扰程度>3分的营养相关症状有疼痛、吞咽困难、口腔溃疡、味觉改变和食欲不振;总体健康状况得分为(51.47±21.48)分。营养不良患者与营养正常患者相比,营养相关症状频率总分更高(40.09±9.23)分比(33.63±9.13)分,P<0.01;对进食干扰程度总分更高(30.97±6.53)分比(25.85±6.54)分,P<0.01;而总体健康状况得分则更低(48.10±20.59)分比(58.97±21.67)分,P=0.001。结论HNC患者放疗结束时营养不良发生率高,营养相关症状普遍且对进食影响大,营养不良患者的营养相关症状更多、更重,生活质量更差,提示医护人员应持续关注放疗结束后HNC患者的营养状况和营养相关症状情况,进行营养干预及症状管理,以改善其生活质量。展开更多
锂离子电池的健康状态(state of health,SOH)是电池管理系统的核心问题,对其精确的评估能够保障电池的安全可靠运行。然而在实际应用中,容量较难直接测得,导致SOH估算困难。为了获得准确的SOH,本文提出一种基于注意力改进双向门控循环单...锂离子电池的健康状态(state of health,SOH)是电池管理系统的核心问题,对其精确的评估能够保障电池的安全可靠运行。然而在实际应用中,容量较难直接测得,导致SOH估算困难。为了获得准确的SOH,本文提出一种基于注意力改进双向门控循环单元(BiGRU)的锂离子电池SOH估计方法。首先提取电池充放电曲线中的电压、电流与阻抗等参数,通过自编码器(auto encoder,AE)对其降维,提取特征量并减少数据间的冗余性。其次,引入注意力机制(attention mechanism,AM)对输入变量分配权重,突出对SOH估计起到关键作用的特征量。最后,利用BiGRU学习输入变量与容量之间的映射关系,捕获容量衰减下的长期依赖性。在不同充电倍率的电池数据集上的结果表明,该方法对不同类型电池的SOH皆可以实现高精度估计,均方根误差在1.1%以下。展开更多
目的:观察头颈部恶性肿瘤患者放射治疗期间骨骼肌量的变化,并分析其影响因素。方法:采用便利取样方法,选取2017年3月至2019年9月在北京市某专科肿瘤医院放射治疗科接受放射治疗的头颈部恶性肿瘤患者为研究对象,应用患者参与主观全面评定...目的:观察头颈部恶性肿瘤患者放射治疗期间骨骼肌量的变化,并分析其影响因素。方法:采用便利取样方法,选取2017年3月至2019年9月在北京市某专科肿瘤医院放射治疗科接受放射治疗的头颈部恶性肿瘤患者为研究对象,应用患者参与主观全面评定(Patient Generated Subjective Global Assessment,PGSGA)的症状部分评估患者在放疗开始前(T1)、放疗中期(T2)、放疗结束时(T3)的营养相关症状(NutritionImpactSymptoms,NIS),用24h膳食回顾法记录膳食摄入情况并采用生物电阻抗分析法测定骨骼肌量变化情况,采用广义估计方程(GeneralizedEstimatingEquations,GEE)分析患者骨骼肌量变化的影响因素。结果:共459例患者完成3次测评。在3个测评时间点,骨骼肌量分别为(26.31±5.08)kg、(25.60±4.83)kg、(24.62±4.68)kg;NIS发生率分别为38.1%(175/459)、93.2%(428/459)、95.4%(438/459);标准化每日能量摄入量(standardDailyEnergyIntake,stDEI)分别为(24.94±8.51)kcal/(kg·day)、(20.47±9.14)kcal/(kg·day)、(18.23±9.75)kcal/(kg·day),标准化每日蛋白摄入量(standard Daily Protein Intake,stDPI)分别为(0.98±0.39)g/(kg·day)(、0.86±0.39)g/(kg·day)、(0.84±0.51)g/(kg·day);随放射治疗的进行,患者骨骼肌量逐渐下降、NIS得分逐渐增加、能量及蛋白质摄入逐渐减少。骨骼肌量变化与放疗前是否手术、膳食能量摄入量及NIS得分密切相关。结论:头颈部恶性肿瘤放射治疗患者治疗后骨骼肌量减少,放疗前未手术、膳食能量摄入不足及NIS重的患者骨骼肌量减少多。提示应重视未手术患者,加强营养相关症状管理和膳食干预,以减轻患者骨骼肌量的丢失。展开更多
The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international partners.The complex comprises four accelerators:a 3...The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international partners.The complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs factory.In its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs bosons.Increasing the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of magnitude.This Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering aspects.Additionally,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection procedures.Construction is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 years.The commencement of experiments and data collection could potentially be initiated in the mid-2030s.展开更多
The catalytic ozonation treatment of secondary biochemical effluent for papermaking wastewater by Ag-doped nickel ferrite was investigated.Ag-doped catalysts prepared by sol-gel method were characterized,illustrating ...The catalytic ozonation treatment of secondary biochemical effluent for papermaking wastewater by Ag-doped nickel ferrite was investigated.Ag-doped catalysts prepared by sol-gel method were characterized,illustrating that Ag entirely entered the crystalline of Ni Fe2O4 and changed the surface properties.The addition of catalyst enhanced the removal efficiency of chemical oxygen demand and total organic carbon.The results of gas chromatography-mass spectrometer,ultraviolet light absorbance at 254 nm and threedimensional fluorescence excitation-emission matrix suggested that aromatic compounds were efficiently degraded and toxic substances,such as dibutyl phthalate.In addition,the radical scavenging experiments confirmed the hydroxyl radicals acted as the main reactive oxygen species and the surface properties of catalysts played an important role in the reaction.Overall,this work validated potential applications of Ag-doped Ni Fe2O4 catalyzed ozonation process of biologically recalcitrant wastewater.展开更多
文摘锂离子电池的健康状态(state of health,SOH)是电池管理系统的核心问题,对其精确的评估能够保障电池的安全可靠运行。然而在实际应用中,容量较难直接测得,导致SOH估算困难。为了获得准确的SOH,本文提出一种基于注意力改进双向门控循环单元(BiGRU)的锂离子电池SOH估计方法。首先提取电池充放电曲线中的电压、电流与阻抗等参数,通过自编码器(auto encoder,AE)对其降维,提取特征量并减少数据间的冗余性。其次,引入注意力机制(attention mechanism,AM)对输入变量分配权重,突出对SOH估计起到关键作用的特征量。最后,利用BiGRU学习输入变量与容量之间的映射关系,捕获容量衰减下的长期依赖性。在不同充电倍率的电池数据集上的结果表明,该方法对不同类型电池的SOH皆可以实现高精度估计,均方根误差在1.1%以下。
文摘目的:观察头颈部恶性肿瘤患者放射治疗期间骨骼肌量的变化,并分析其影响因素。方法:采用便利取样方法,选取2017年3月至2019年9月在北京市某专科肿瘤医院放射治疗科接受放射治疗的头颈部恶性肿瘤患者为研究对象,应用患者参与主观全面评定(Patient Generated Subjective Global Assessment,PGSGA)的症状部分评估患者在放疗开始前(T1)、放疗中期(T2)、放疗结束时(T3)的营养相关症状(NutritionImpactSymptoms,NIS),用24h膳食回顾法记录膳食摄入情况并采用生物电阻抗分析法测定骨骼肌量变化情况,采用广义估计方程(GeneralizedEstimatingEquations,GEE)分析患者骨骼肌量变化的影响因素。结果:共459例患者完成3次测评。在3个测评时间点,骨骼肌量分别为(26.31±5.08)kg、(25.60±4.83)kg、(24.62±4.68)kg;NIS发生率分别为38.1%(175/459)、93.2%(428/459)、95.4%(438/459);标准化每日能量摄入量(standardDailyEnergyIntake,stDEI)分别为(24.94±8.51)kcal/(kg·day)、(20.47±9.14)kcal/(kg·day)、(18.23±9.75)kcal/(kg·day),标准化每日蛋白摄入量(standard Daily Protein Intake,stDPI)分别为(0.98±0.39)g/(kg·day)(、0.86±0.39)g/(kg·day)、(0.84±0.51)g/(kg·day);随放射治疗的进行,患者骨骼肌量逐渐下降、NIS得分逐渐增加、能量及蛋白质摄入逐渐减少。骨骼肌量变化与放疗前是否手术、膳食能量摄入量及NIS得分密切相关。结论:头颈部恶性肿瘤放射治疗患者治疗后骨骼肌量减少,放疗前未手术、膳食能量摄入不足及NIS重的患者骨骼肌量减少多。提示应重视未手术患者,加强营养相关症状管理和膳食干预,以减轻患者骨骼肌量的丢失。
基金support from diverse funding sources,including the National Key Program for S&T Research and Development of the Ministry of Science and Technology(MOST),Yifang Wang's Science Studio of the Ten Thousand Talents Project,the CAS Key Foreign Cooperation Grant,the National Natural Science Foundation of China(NSFC)Beijing Municipal Science&Technology Commission,the CAS Focused Science Grant,the IHEP Innovation Grant,the CAS Lead Special Training Programthe CAS Center for Excellence in Particle Physics,the CAS International Partnership Program,and the CAS/SAFEA International Partnership Program for Creative Research Teams.
文摘The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international partners.The complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs factory.In its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs bosons.Increasing the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of magnitude.This Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering aspects.Additionally,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection procedures.Construction is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 years.The commencement of experiments and data collection could potentially be initiated in the mid-2030s.
基金supported by National Key R&D Program of China(No.2018YFC0406300)the operation for central university of Hohai University(No.2013/B18020148)A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions。
文摘The catalytic ozonation treatment of secondary biochemical effluent for papermaking wastewater by Ag-doped nickel ferrite was investigated.Ag-doped catalysts prepared by sol-gel method were characterized,illustrating that Ag entirely entered the crystalline of Ni Fe2O4 and changed the surface properties.The addition of catalyst enhanced the removal efficiency of chemical oxygen demand and total organic carbon.The results of gas chromatography-mass spectrometer,ultraviolet light absorbance at 254 nm and threedimensional fluorescence excitation-emission matrix suggested that aromatic compounds were efficiently degraded and toxic substances,such as dibutyl phthalate.In addition,the radical scavenging experiments confirmed the hydroxyl radicals acted as the main reactive oxygen species and the surface properties of catalysts played an important role in the reaction.Overall,this work validated potential applications of Ag-doped Ni Fe2O4 catalyzed ozonation process of biologically recalcitrant wastewater.
