摘要
目的分析糖尿病家族史与成人糖尿病发病的关联。方法使用中国慢性病前瞻性研究(CKB)苏州市吴中区数据,剔除基线时患冠心病、脑卒中、恶性肿瘤、糖尿病的个体,共49266名研究对象纳入分析。随访人年数的计算从研究对象完成基线调查时开始,至最早出现以下任一事件的时间终止:糖尿病发病、死亡、失访或2013年12月31日。采用Cox比例风险模型计算糖尿病家族史与糖尿病发病风险比(HR)。结果研究对象累计随访348677人年(平均随访7.08年)。随访期间,男性423例和女性791例被新诊断为糖尿病。与无家族史者相比,有家族史者发生糖尿病的风险增加,HR(95%CI)值为1.90(1.57~2.29),并且个体具有糖尿病病史的亲属数量越多,发生糖尿病的风险越高(P趋势<0.05)。母亲型、同胞型和同胞双亲型家族史与糖尿病发病风险关联均有统计学意义,HR(95%CI)值分别为2.03(1.45~2.77)、2.07(1.56~2.68)和2.39(1.14~4.34)。未发现吸烟、饮酒、体重指数和体力活动对糖尿病家族史与糖尿病之间的关联存在效应修饰作用(P交互>0.05)。结论糖尿病家族史可增加糖尿病的发病风险,且发病风险随着家属中有糖尿病史者的增加而升高。
Objective To evaluate the association betweew family history of diabetes and incident diabetes of adults.Methods A total of 49266 participants in the China Kadoorie Biobank(CKB)study from Wuzhong district of Suzhou city were included in the analysis,after the exclusion of those with heart disease,stroke,cancer and diabetes at baseline survey.The person-year of follow-up was calculated from the date on completion of baseline survey to the date on any firstly-occurred event,i.e.,diabetes incidence,death,loss of follow-up,or December 31,2013.Cox regression model was used to estimate the hazards ratios of the association between family history of diabetes and incident diabetes.Results During 348677 person-years of the follow-up(median 7.08 years),a total of 423 men and 791 women were diagnosed as having diabetes.Compared to those without diabetic family history,participants with family history of diabetes showed a higher risk of diabetes,with a HR(95%CI)of 1.90(1.57-2.29),and the risk increased with the number of relatives suffering from diabetes(Pfor trend<0.05).The family history of maternal type,sibling type,and sibling and parental type had a statistically significant association with the risk of diabetes.The adjusted HR(95%CI)was 2.03(1.45-2.77),2.07(1.56-2.68)and 2.39(1.14-4.34),respectively.Modification effects of tobacco smoking,alcohol drinking,body mass index and physical activity on the association between diabetic family history and risk of diabetes were not observed in the study(Pfor interaction>0.05).Conclusions Diabetic family history is associated with the increased incident diabetes,and the risk increased with the number of relatives suffering from diabetes.
作者
苏健
周金意
陶然
万亚男
覃玉
陆艳
华钰洁
金建荣
卞铮
郭彧
陈铮鸣
武鸣
李立明
Su Jian;Zhou Jinyi;Tao Ran;Wan Yanan;Qin Yu;Lu Yan;Hua Yujie;Jin Jianrong;Bian Zheng;Guo Yu;Chen Zhengming;Wu Ming;Li Liming(Department of Non-communicable Chronic Disease Control and Prevention,Jiangsu Provincial Center for Disease Control and Prevention,Nanjing 210009,China;Department of Non-communicable Chronic Disease Control and Prevention,Suzhou City Center for Disease Control and Prevention,Suzhou 215004,China;Wuzhong Ditrict of Suzhou City Center for Disease Control and Prevention,Suzhou 215100,China;Department of China Kadoorie Biobank,Chinese Academy of Medical Sciences,Beijing 102308,China;Clinical Trial Service Unit and Epidemiological Studies Unit,University of Oxford,Oxford OX37LF,UK;School of Public Health,Peking University,Beijing 100191,China)
出处
《中华预防医学杂志》
CAS
CSCD
北大核心
2020年第8期828-833,共6页
Chinese Journal of Preventive Medicine
基金
国家重点研发计划精准医学研究重点专项(2016YFC0900500,2016YFC0900501)
中国香港Kadooric Charitable基金
英国Wellcome Trust(202922/Z/16/Z,088158/Z/09/Z,104085/Z/14/Z)
江苏省医学领军人才和创新团队项目(K201105)
江苏省疾病预防控制中心科教强业工程青年人才项目(JKRC2016007)。
关键词
家族史
糖尿病
前瞻性研究
Family history
Diabetes
Prospective study
