Background Diabetes mellitus is associated with coronary dysfunction, contributing to a 2- to 4-fold increase in the risk of coronary heart diseases. The mechanisms by which diabetes induces vasculopathy involve endot...Background Diabetes mellitus is associated with coronary dysfunction, contributing to a 2- to 4-fold increase in the risk of coronary heart diseases. The mechanisms by which diabetes induces vasculopathy involve endothelial-dependent and -independent vascular dysfunction in both type 1 and type 2 diabetes mellitus. The purpose of this study is to determine the role of vascular large conductance Ca2＋-activated K＋ （BK） channel activities in coronary dysfunction in streptozotocin-induced diabetic rats. Methods Using videomicroscopy, immunoblotting, fluorescent assay and patch clamp techniques, we investigated the coronary BK channel activities and BK channel-mediated coronary vasoreactivity in streptozotocin-induced diabetic rats. Results BK currents （defined as the iberiotoxin-sensitive K＋ component） contribute （65＋4）% of the total K＋currents in freshly isolated coronary smooth muscle cells and 〉50% of the contraction of the inner diameter of coronary arteries from normal rats. However, BK current density is remarkably reduced in coronary smooth muscle cells of streptozotocin-induced diabetic rats, leading to an increase in coronary artery tension. BK channel activity in response to free Ca2＋ iS impaired in diabetic rats. Moreover, cytoplasmic application of DHS-1 （a specific BK channel i~ subunit activator） robustly enhanced the open probability of BK channels in coronary smooth muscle cells of normal rats. In diabetic rats, the DHS-1 effect was diminished in the presence of 200 nmol/L Ca2＋ and was significantly attenuated in the presence of high free calcium concentration, i.e., 1 μmol/L Ca2＋. Immunoblotting experiments confirmed that there was a 2-fold decrease in BK-β1 protein expression in diabetic vessels, without alterinq the BK channel a-subunit expression.Although the cytosolic Ca2＋ concentration of coronary arterial smooth muscle cells was increased from （103±23） nmol/L （n=5） of control rats to （193±22） nmol/L （n=6, P 〈0.05） of STZ-induced diabetic展开更多
The causal correlation or linkage between the East Asian Monsoon (EAM) intensity and rise/fall of Chinese dynasties recently proposed by high-resolution paleoclimate reconstructions is examined in detail. Aside from m...The causal correlation or linkage between the East Asian Monsoon (EAM) intensity and rise/fall of Chinese dynasties recently proposed by high-resolution paleoclimate reconstructions is examined in detail. Aside from many exceptions to the correlation, both instrumental and historical climate records show strong spatial variations of rainfall on annual-to-decadal scales over eastern China. The relationship between rainfall and EAM intensity also exhibits regional disparity. These observations suggest: (1) Tak-ing paleo-proxy records from a single locality in eastern China to imply changes in drought/wetness as to affect the cultural and political history of China is fraught with uncertainty. (2) On annual-to-decadal scales, the thesis that δ18O in speleothems can be used as a proxy for the EAM strength lacks empirical underpinnings.展开更多
We thank Cheng et al. for their interest in our paper 'On linking climate to Chinese dynastic change: Spatial and temporal variations of of monsoonal rain' [1]. Our paper was written largely as a response to t...We thank Cheng et al. for their interest in our paper 'On linking climate to Chinese dynastic change: Spatial and temporal variations of of monsoonal rain' [1]. Our paper was written largely as a response to the suggestion made展开更多
Carbon capture and storage(CCS)technology is an imperative,strategic,and constitutive method to considerably reduce anthropogenic CO_(2)emissions and alleviate climate change issues.The ocean is the largest active car...Carbon capture and storage(CCS)technology is an imperative,strategic,and constitutive method to considerably reduce anthropogenic CO_(2)emissions and alleviate climate change issues.The ocean is the largest active carbon bank and an essential energy source on the Earth's surface.Compared to oceanic nature-based carbon dioxide removal(CDR),carbon capture from point sources with ocean storage is more appropriate for solving short-term climate change problems.This review focuses on the recent state-of-the-art developments in offshore carbon storage.It first discusses the current status and development prospects of CCS,associated with the chailenges and uncertainties of oceanic nature-based CDR.The second section outlines the mechanisms,sites,advantages,and ecologic hazards of direct offshore CO_(2)injection.The third section emphasizes the mechanisms,schemes,influencing factors,and recovery efficiency of ocean-based CO-CH_(4)replacement and CO_(2)-enhanced oil recovery are reviewed.In addition,this review discusses the economic aspects of offshore CCS and the preponderance of offshore CCs hubs.Finally,the upsides,limitations,and prospects for further investigation of offshore CO_(2)storage are presented.展开更多
The surface-modified zinc phosphate (Zn3(PO4)2) nanocrystals were synthesized by a facile and efficient one-step ultrasonic-template-microwave (UTM) assisted route. The crystal structure, optical properties and morpho...The surface-modified zinc phosphate (Zn3(PO4)2) nanocrystals were synthesized by a facile and efficient one-step ultrasonic-template-microwave (UTM) assisted route. The crystal structure, optical properties and morphologies of zinc phosphate nanocrystals were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, Raman spectroscopy and transmission electron microscope. And the TEM image showed that the product had good dispersion with a particle size of 30 – 35 nm. The anti-corrosion function of anti-corrosive paint using zinc phosphate nanocrystals was researched and the experiment result showed that the salt atmosphere–resistant time was 158 h longer than that of zinc phosphate bulk materials on market. The performance of zinc phosphate nanocrystals with modified surface synthesized by one-step UTM assisted route was improved 63.2% compared with the bulk materials.展开更多
Mammalian target of rapamycin(m TOR) inhibitor as an attractive drug target with promising antitumor effects has been widely investigated. High quality clinical trial has been conducted in liver transplant(LT) recipie...Mammalian target of rapamycin(m TOR) inhibitor as an attractive drug target with promising antitumor effects has been widely investigated. High quality clinical trial has been conducted in liver transplant(LT) recipients in Western countries. However, the pertinent studies in Eastern world are paucity. Therefore, we designed a clinical trial to test whether sirolimus can improve recurrence-free survival(RFS) in hepatocellular carcinoma(HCC) patients beyond the Milan criteria after LT. This is an open-labeled, single-arm, prospective, multicenter, and real-world study aiming to evaluate the clinical outcomes of early switch to sirolimus-based regimens in HCC patients after LT. Patients with a histologically proven HCC and beyond the Milan criteria will be enrolled. The initial immunosuppressant regimens are center-specifc for the frst 4-6 weeks. The following regimens integrated sirolimus into the regimens as a combination therapy with reduced calcineurin inhibitors based on the condition of patients and centers. The study is planned for 4 years in total with a 2-year enrollment period and a 2-year follow-up. We predict that sirolimus conversion regimen will provide survival benefts for patients particular in the key indicator RFS as well as better quality of life. If the trial is conducted successfully, we will have a continued monitoring over a longer follow-up time to estimate indicator of overall survival. We hope that the outcome will provide better evidence for clinical decision-making and revising treatment guidelines based on Chinese population data.展开更多
Surgery such as digestive tract reconstruction is usually required for pancreatic trauma and severe pancreatitis as well as malignant pancreatic lesions. The most common digestive tract reconstruction techniques (e.g....Surgery such as digestive tract reconstruction is usually required for pancreatic trauma and severe pancreatitis as well as malignant pancreatic lesions. The most common digestive tract reconstruction techniques (e.g., Child’s type reconstruction) for neoplastic diseases of the pancreatic head often encompass pancreaticojejunostomy, choledochojejunostomy and then gastrojejunostomy with pancreaticoduodenectomy, whereas these techniques may not be applicable in benign pancreatic diseases due to an integrated stomach and duodenum in these patients. In benign pancreatic diseases, the aforementioned reconstruction will not only increase the distance between the pancreaticojejunostomy and choledochojejunostomy, but also the risks of traction, twisting and angularity of the jejunal loop. In addition, postoperative complications such as mixed fistula are refractory and life-threatening after common reconstruction procedures. We here introduce a novel pancreaticojejunostomy, hepaticojejunostomy and double Roux-en-Y digestive tract reconstruction in two cases of benign pancreatic disease, thus decreasing not only the distance between the pancreaticojejunostomy and choledochojejunostomy, but also the possibility of postoperative complications compared to common reconstruction methods. Postoperatively, the recovery of these patients was uneventful and complications such as bile leakage, pancreatic leakage and digestive tract obstruction were not observed during the follow-up period.展开更多
氢电导率是电力机组重点监控的水汽指标之一。由于氢型树脂交换容量限制,运行一段时间后样水中添加的碱化剂会穿透,从而造成氢电导率测值失效。在联合循环电厂,基于热力设备防腐处理要求,给水中需添加较多碱化剂,给水高pH值环境运行,易...氢电导率是电力机组重点监控的水汽指标之一。由于氢型树脂交换容量限制,运行一段时间后样水中添加的碱化剂会穿透,从而造成氢电导率测值失效。在联合循环电厂,基于热力设备防腐处理要求,给水中需添加较多碱化剂,给水高pH值环境运行,易引起水汽循环系统氢电导率监控不连续,热力设备发生腐蚀风险不可控,表计频繁维护管理难度大,失效指标虚假报警化学监督平台等问题。为解决上述实际困难问题,某电厂调查研究了传统阳树脂法与氢型电除盐法的原理区别,采用以氢型电除盐为核心技术的阳离子交换后的电导率(conductivity after cation exchanger,CACE)表计测量,实现了氢电导率准确、连续、可靠监测,取得非常满意的应用效果。展开更多
An operation strategy of the electric vehicle （EV） battery charging and swapping station is proposed in the paper. The strategy is established based on comprehensively consideration of the EV charging behaviors and ...An operation strategy of the electric vehicle （EV） battery charging and swapping station is proposed in the paper. The strategy is established based on comprehensively consideration of the EV charging behaviors and the possible mutual actions between battery charging and swapping. Three energy management strategies can be used in the station： charging period shifting, energy exchange between EVs, and energy supporting from surplus swapping batteries. Then an optimization model which minimizes the total energy management costs of the station is built. The Monte Carlo simulation is applied to analyze the characteristics of the EV battery charging load, and a heuristic algorithm is used to solve the strategy providing the relevant information of EVs and the battery charging and swapping station. The operation strategy can efficiently reduce battery charging during the high electricity price periods and make more reasonable use of the resources. Simulations prove the feasibility and rationality of the strategy.展开更多
Light nuclei are few-body quantal systems and historically their spectra were thefirst to be studied experimentally.In a recent review,the existing experimental data from the stable N¼Z doubly-odd nuclei and spect...Light nuclei are few-body quantal systems and historically their spectra were thefirst to be studied experimentally.In a recent review,the existing experimental data from the stable N¼Z doubly-odd nuclei and spectroscopic studies have been discussed,as well as the b decay of the corresponding isobaric multiplets[1].The description of nuclear many-body systems derived fromfirst principles remains one of the most challenging research areas over the past decades because of the complex nature and limited knowledge of fundamental forces among nucleons,emerging from either meson-exchange theory or quantum chromodynamics(QCD).展开更多
基金the National Natural Science Foundation of China，Natural Science Foundation of Jiangsu Province，Medical Key Personnel of Jiangsu Province，Top Qualified Personnel in Six Fields of Jiangsu Province (006) to WANG Ru-xing and the American Diabetes Association Junior Faculty Awards
文摘Background Diabetes mellitus is associated with coronary dysfunction, contributing to a 2- to 4-fold increase in the risk of coronary heart diseases. The mechanisms by which diabetes induces vasculopathy involve endothelial-dependent and -independent vascular dysfunction in both type 1 and type 2 diabetes mellitus. The purpose of this study is to determine the role of vascular large conductance Ca2＋-activated K＋ （BK） channel activities in coronary dysfunction in streptozotocin-induced diabetic rats. Methods Using videomicroscopy, immunoblotting, fluorescent assay and patch clamp techniques, we investigated the coronary BK channel activities and BK channel-mediated coronary vasoreactivity in streptozotocin-induced diabetic rats. Results BK currents （defined as the iberiotoxin-sensitive K＋ component） contribute （65＋4）% of the total K＋currents in freshly isolated coronary smooth muscle cells and 〉50% of the contraction of the inner diameter of coronary arteries from normal rats. However, BK current density is remarkably reduced in coronary smooth muscle cells of streptozotocin-induced diabetic rats, leading to an increase in coronary artery tension. BK channel activity in response to free Ca2＋ iS impaired in diabetic rats. Moreover, cytoplasmic application of DHS-1 （a specific BK channel i~ subunit activator） robustly enhanced the open probability of BK channels in coronary smooth muscle cells of normal rats. In diabetic rats, the DHS-1 effect was diminished in the presence of 200 nmol/L Ca2＋ and was significantly attenuated in the presence of high free calcium concentration, i.e., 1 μmol/L Ca2＋. Immunoblotting experiments confirmed that there was a 2-fold decrease in BK-β1 protein expression in diabetic vessels, without alterinq the BK channel a-subunit expression.Although the cytosolic Ca2＋ concentration of coronary arterial smooth muscle cells was increased from （103±23） nmol/L （n=5） of control rats to （193±22） nmol/L （n=6, P 〈0.05） of STZ-induced diabetic
基金supported by the Science Council of Taiwan (NSC 97-2628-M-006-014)the National Natural Science Foundation of China (Grant Nos 40672202 and 40599424)
文摘The causal correlation or linkage between the East Asian Monsoon (EAM) intensity and rise/fall of Chinese dynasties recently proposed by high-resolution paleoclimate reconstructions is examined in detail. Aside from many exceptions to the correlation, both instrumental and historical climate records show strong spatial variations of rainfall on annual-to-decadal scales over eastern China. The relationship between rainfall and EAM intensity also exhibits regional disparity. These observations suggest: (1) Tak-ing paleo-proxy records from a single locality in eastern China to imply changes in drought/wetness as to affect the cultural and political history of China is fraught with uncertainty. (2) On annual-to-decadal scales, the thesis that δ18O in speleothems can be used as a proxy for the EAM strength lacks empirical underpinnings.
基金supported by the China Global Change Research Program (2010CB950103)
文摘We thank Cheng et al. for their interest in our paper 'On linking climate to Chinese dynastic change: Spatial and temporal variations of of monsoonal rain' [1]. Our paper was written largely as a response to the suggestion made
基金the financial support from the Science and Technology Commission of Shanghai Municipality(No.21DZ1206200)the Shanghai Agriculture Science and Technology Program(No.2022-02-08-00-12-F01176)the financial support from the National Natural Science Foundation of China(Nos.52006135 and 72140008),respectively.
文摘Carbon capture and storage(CCS)technology is an imperative,strategic,and constitutive method to considerably reduce anthropogenic CO_(2)emissions and alleviate climate change issues.The ocean is the largest active carbon bank and an essential energy source on the Earth's surface.Compared to oceanic nature-based carbon dioxide removal(CDR),carbon capture from point sources with ocean storage is more appropriate for solving short-term climate change problems.This review focuses on the recent state-of-the-art developments in offshore carbon storage.It first discusses the current status and development prospects of CCS,associated with the chailenges and uncertainties of oceanic nature-based CDR.The second section outlines the mechanisms,sites,advantages,and ecologic hazards of direct offshore CO_(2)injection.The third section emphasizes the mechanisms,schemes,influencing factors,and recovery efficiency of ocean-based CO-CH_(4)replacement and CO_(2)-enhanced oil recovery are reviewed.In addition,this review discusses the economic aspects of offshore CCS and the preponderance of offshore CCs hubs.Finally,the upsides,limitations,and prospects for further investigation of offshore CO_(2)storage are presented.
文摘The surface-modified zinc phosphate (Zn3(PO4)2) nanocrystals were synthesized by a facile and efficient one-step ultrasonic-template-microwave (UTM) assisted route. The crystal structure, optical properties and morphologies of zinc phosphate nanocrystals were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, Raman spectroscopy and transmission electron microscope. And the TEM image showed that the product had good dispersion with a particle size of 30 – 35 nm. The anti-corrosion function of anti-corrosive paint using zinc phosphate nanocrystals was researched and the experiment result showed that the salt atmosphere–resistant time was 158 h longer than that of zinc phosphate bulk materials on market. The performance of zinc phosphate nanocrystals with modified surface synthesized by one-step UTM assisted route was improved 63.2% compared with the bulk materials.
基金supported by grants from the National S&T Major Project (2017ZX10203205)Key Program,National Natural Science Foundation of China (81930016)Zhejiang Provincial Natural Science Foundation of China (LY21H160026)。
文摘Mammalian target of rapamycin(m TOR) inhibitor as an attractive drug target with promising antitumor effects has been widely investigated. High quality clinical trial has been conducted in liver transplant(LT) recipients in Western countries. However, the pertinent studies in Eastern world are paucity. Therefore, we designed a clinical trial to test whether sirolimus can improve recurrence-free survival(RFS) in hepatocellular carcinoma(HCC) patients beyond the Milan criteria after LT. This is an open-labeled, single-arm, prospective, multicenter, and real-world study aiming to evaluate the clinical outcomes of early switch to sirolimus-based regimens in HCC patients after LT. Patients with a histologically proven HCC and beyond the Milan criteria will be enrolled. The initial immunosuppressant regimens are center-specifc for the frst 4-6 weeks. The following regimens integrated sirolimus into the regimens as a combination therapy with reduced calcineurin inhibitors based on the condition of patients and centers. The study is planned for 4 years in total with a 2-year enrollment period and a 2-year follow-up. We predict that sirolimus conversion regimen will provide survival benefts for patients particular in the key indicator RFS as well as better quality of life. If the trial is conducted successfully, we will have a continued monitoring over a longer follow-up time to estimate indicator of overall survival. We hope that the outcome will provide better evidence for clinical decision-making and revising treatment guidelines based on Chinese population data.
基金Supported by Major Program of Science and Technology Bureau of Hainan Province,No.ZDXM2014074
文摘Surgery such as digestive tract reconstruction is usually required for pancreatic trauma and severe pancreatitis as well as malignant pancreatic lesions. The most common digestive tract reconstruction techniques (e.g., Child’s type reconstruction) for neoplastic diseases of the pancreatic head often encompass pancreaticojejunostomy, choledochojejunostomy and then gastrojejunostomy with pancreaticoduodenectomy, whereas these techniques may not be applicable in benign pancreatic diseases due to an integrated stomach and duodenum in these patients. In benign pancreatic diseases, the aforementioned reconstruction will not only increase the distance between the pancreaticojejunostomy and choledochojejunostomy, but also the risks of traction, twisting and angularity of the jejunal loop. In addition, postoperative complications such as mixed fistula are refractory and life-threatening after common reconstruction procedures. We here introduce a novel pancreaticojejunostomy, hepaticojejunostomy and double Roux-en-Y digestive tract reconstruction in two cases of benign pancreatic disease, thus decreasing not only the distance between the pancreaticojejunostomy and choledochojejunostomy, but also the possibility of postoperative complications compared to common reconstruction methods. Postoperatively, the recovery of these patients was uneventful and complications such as bile leakage, pancreatic leakage and digestive tract obstruction were not observed during the follow-up period.
文摘氢电导率是电力机组重点监控的水汽指标之一。由于氢型树脂交换容量限制,运行一段时间后样水中添加的碱化剂会穿透,从而造成氢电导率测值失效。在联合循环电厂,基于热力设备防腐处理要求,给水中需添加较多碱化剂,给水高pH值环境运行,易引起水汽循环系统氢电导率监控不连续,热力设备发生腐蚀风险不可控,表计频繁维护管理难度大,失效指标虚假报警化学监督平台等问题。为解决上述实际困难问题,某电厂调查研究了传统阳树脂法与氢型电除盐法的原理区别,采用以氢型电除盐为核心技术的阳离子交换后的电导率(conductivity after cation exchanger,CACE)表计测量,实现了氢电导率准确、连续、可靠监测,取得非常满意的应用效果。
基金supported by the National Natural Science Foundation of China under Grant No.51007047
文摘An operation strategy of the electric vehicle （EV） battery charging and swapping station is proposed in the paper. The strategy is established based on comprehensively consideration of the EV charging behaviors and the possible mutual actions between battery charging and swapping. Three energy management strategies can be used in the station： charging period shifting, energy exchange between EVs, and energy supporting from surplus swapping batteries. Then an optimization model which minimizes the total energy management costs of the station is built. The Monte Carlo simulation is applied to analyze the characteristics of the EV battery charging load, and a heuristic algorithm is used to solve the strategy providing the relevant information of EVs and the battery charging and swapping station. The operation strategy can efficiently reduce battery charging during the high electricity price periods and make more reasonable use of the resources. Simulations prove the feasibility and rationality of the strategy.
基金supported partially by the Romanian Ministry of Research and Innovation under research contract PN23210106,ELI-RO-RDI-2024-002ELI-RO-RDI-2024-007 project sponsored by the Romanian Ministry of Research,Innovation and Digitization.
文摘Light nuclei are few-body quantal systems and historically their spectra were thefirst to be studied experimentally.In a recent review,the existing experimental data from the stable N¼Z doubly-odd nuclei and spectroscopic studies have been discussed,as well as the b decay of the corresponding isobaric multiplets[1].The description of nuclear many-body systems derived fromfirst principles remains one of the most challenging research areas over the past decades because of the complex nature and limited knowledge of fundamental forces among nucleons,emerging from either meson-exchange theory or quantum chromodynamics(QCD).
