The microwave absorbents of Fe and C nanoparticles as magnetic loss and dielectric loss material respectively were composited with the polyvinyl alcohol （PVA） as binder by spray granulation method, The electromagnet...The microwave absorbents of Fe and C nanoparticles as magnetic loss and dielectric loss material respectively were composited with the polyvinyl alcohol （PVA） as binder by spray granulation method, The electromagnetic parameters of Fe and C composite particles were analyzed by vector network. The complex permittivity and magnetic permeability of Fe and C composite particles matched well with increasing C nanoparticle content, and then the microwave loss property was improved. A minimum reflection loss （RL） of -42.7 dB at 3.68 GHz for a composite with 4.6 mm in thickness can be obtained when the content ratio of the C nanoparticles, the modified Fe nanoparticles and the PVA is 21：49：30 （Sample 3）.展开更多
The heat transfer enhancement characteristics of water with polystyrene particles are examined in the present numerical study. The numerical study is conducted in the hydrodynamically fully developed turbulent flows w...The heat transfer enhancement characteristics of water with polystyrene particles are examined in the present numerical study. The numerical study is conducted in the hydrodynamically fully developed turbulent flows within a circular duct with the wall boundary condition of a constant heat flux. The thermal conductivity of the turbulent flow obtained by the Reynolds analogy is 1000 times as much as the thermal conductivity of water. On the contrary, the enhancement of thermal conductivity caused by water-microparticles suspension is relatively low. Slight enhancements of the local Nusselt number are obtained in the numerical calculations of Newtonian turbulent flows with the micro-convection effects, thus showing large deviations from the experimental data. The numerical results in non-Newtonian flows are in agreement with the experimental data. Thus, the main cause for the enhancement of the heat transfer of the suspension might be not due to the micro-convection effects but to the non-Newtonian展开更多
From April to July 2018,a data sample at the peak energy of the T(4 S) resonance was collected with the Belle Ⅱ detector at the SuperKEKB electron-positron collider.This is the first data sample of the Belle Ⅱ exper...From April to July 2018,a data sample at the peak energy of the T(4 S) resonance was collected with the Belle Ⅱ detector at the SuperKEKB electron-positron collider.This is the first data sample of the Belle Ⅱ experiment.Using Bhabha and digamma events,we measure the integrated luminosity of the data sample to be(496.3±0.3±3.0) pb-1,where the first uncertainty is statistical and the second is systematic.This work provides a basis for future luminosity measurements at Belle Ⅱ.展开更多
The isotope ratio mass spectrometer (IRMS) is an instrument that measures both of the elemental contents and isotope ratios of hydrogen, oxygen, carbon, nitrogen and sulfur in environmental samples at the same time. I...The isotope ratio mass spectrometer (IRMS) is an instrument that measures both of the elemental contents and isotope ratios of hydrogen, oxygen, carbon, nitrogen and sulfur in environmental samples at the same time. In this study, we want to try to get two main goals;first, to make up for setting the analytical conditions such as accuracy and precision, second, to apply for comparing of the carbon and nitrogen isotope ratio of sediments in the abandoned mine located in middle province of Korea. For the first goal, a recently introduced IRMS was used to analyze CRM (certified reference materials), which helped to make up the analytical conditions of carbon and nitrogen isotope ratios. So, the accuracy and precision of isotope ratios and elemental contents were also assessed simultaneously, and also the results were very satisfactory. The analytical results of carbon reference materials (EMA-P2) showed an accuracy of -2.801 × 10‰ ± 0.01‰ (2σ) and a precision of 0.009‰ in the mass range from 0.008 μg - 0.162 μg. For nitrogen reference materials (EMA-P2), an accuracy of -1.632‰ ± 0.72‰ (2σ) was obtained in the mass range from 0.082 - 0.162 mg. These values of accuracy and precision are higher than those reported by other studies. For the second goal, carbon and nitrogen isotopes in river sediment near abandoned mines were analyzed based on the established analytical conditions. The result suggested that carbon isotope ratios ranged from -22.5‰ - -7.5‰ and nitrogen isotope ratios from -1.9‰ - 7.9‰. By comparing the isotope ratios and sampling sites of sediment, we know that the nitrogen isotope values in samples of entrance area of mine are greater than those of the farm house area, which is indicating the effects of organic materials. So, we could guess that the newly accumulated organic materials were much more in the farm house area than mine entrance area. And a result of this study, the accuracy and precision tests of IRMS using certified reference materials were very satisfactory and opt展开更多
For Al 6k21-T4 overlap weld joint,the shear-tensile strength by using the weaving laser was improved as compared to the case of linear laser.For the specimen of low strength,the porosity was distributed continuously a...For Al 6k21-T4 overlap weld joint,the shear-tensile strength by using the weaving laser was improved as compared to the case of linear laser.For the specimen of low strength,the porosity was distributed continuously along the intersection between the plates and fusion line.However,for the optimized welding condition,large oval-shaped porosities were located only in the advancing track of the concave part.Therefore,the continuity of cracks and porosities played a key role to determine the strength.And,the weaving width was also the important parameter to control the strength.Furthermore,the concave part had more significant hot and cold cracking in the weld and heat-affected zone（HAZ）,respectively,than the convex part.展开更多
The effects of Ca and Sr addition on the microstructure and creep properties of Mg-4Al-2Sn alloys were examined. Tensile tests at 25 ℃ and 200 ℃ and creep tests at 150 ℃ and 200 ℃ were carried out to estimate the ...The effects of Ca and Sr addition on the microstructure and creep properties of Mg-4Al-2Sn alloys were examined. Tensile tests at 25 ℃ and 200 ℃ and creep tests at 150 ℃ and 200 ℃ were carried out to estimate the room temperature and high temperature mechanical properties of these alloys. The microstrueture of the Mg-4Al-2Sn alloy showed dendritic a-Mg, Mg17Al12 and Mg2Sn phases. The latter two phases precipitated along the grain boundaries. The addition of Ca and Sr resulted in the formation of ternary CaMgSn and SrMgSn phases within the grain. The grain size was reduced slightly with the addition of Sr and Ca. The tensile strength was decreased by the addition of Ca and Sr at room temperature. However, the high temperature tensile strength was increased. The creep strength was improved by the addition of Ca and Sr.展开更多
The effects of Si content on combinations of important properties such as hardness, hardenability, and weldability in addition to strength increment were systematically investigated to develop a Mo and V free low allo...The effects of Si content on combinations of important properties such as hardness, hardenability, and weldability in addition to strength increment were systematically investigated to develop a Mo and V free low alloy cast steel for automobile cold pressing die insert. For the evaluation of the applicability as the die insert, the mechanical properties were measured after spheroidization annealing （SA）, quenching and tempering （Q/T）, and flame hardening （FH） treatments, respectively. The developed 0.8%-1.6%Si containing Mo and V free alloy cast steels showed excellent matrix strengthening effect, hardenability, and weldability, fulfilling the industrial criterion of the mechanical properties for the die insert.展开更多
Nanoparticles of Fe-Co alloys and their oxides with the particle size below 20 nm were prepared by chemical vapor condensation process. The pure Ar, Ar+1%O2, Ar+3%O2 and Ar+6%O2 were used as carrier gases, with iron c...Nanoparticles of Fe-Co alloys and their oxides with the particle size below 20 nm were prepared by chemical vapor condensation process. The pure Ar, Ar+1%O2, Ar+3%O2 and Ar+6%O2 were used as carrier gases, with iron carbonyl and cobalt carbonyl as the precursors. XRD patterns showed that Fe-Co metallic nanoparticles were synthesized by using pure Ar as carrier gas, and only metal oxides were obtained using Ar+(>3)%O2 as carrier gas. The HRTEM images and TG-DTA curves were used to study the core-shell structure of the different nanoparticles. The nanoparticles obtained in pure Ar consist of black core and light shell with thickness of 2~4 nm. However, in the particles obtained in Ar+6%02, the oxides core with visible lattice fringes are surrounded by thin shell.展开更多
As there is substantial progress in the KSTAR tokamak engineering, all themajor structures and sub-systems are under fabrication and in procurement phase. The vacuum vessel,port, cryostat cylinder, lid, and bellows ar...As there is substantial progress in the KSTAR tokamak engineering, all themajor structures and sub-systems are under fabrication and in procurement phase. The vacuum vessel,port, cryostat cylinder, lid, and bellows are being rigorously fabricated in the factory. The lowerpart of the KSTAR such as cryostat base and gravity support has been almost finished in itsfabrication. There are also great progresses and significant results in manufacturing of thesuperconducting magnet, including four Toroidal Field (TF) coils, lower and upper PF7 coils whichare the largest Poloidal Field (PF) coils. The TFOO coil, which has been made for test and back-upof the TF magnet system, was successfully tested in the cool-down and current charging. As thefabrications and procurements of major structures have been actively proceeded, assembly works werealso launched from Aug. 2003. More detailed description on these status, results, and plans will bedescribed in this paper.展开更多
Correlation between gas and dust column density has been studied for the dark globule L1523. The 13CO（J=1→0） emission is used for tracing the gas, and the IR emissions, for tracing the dust constituent. In order to...Correlation between gas and dust column density has been studied for the dark globule L1523. The 13CO（J=1→0） emission is used for tracing the gas, and the IR emissions, for tracing the dust constituent. In order to match the beam resolution between the images, a beam de-convolution algorithm based on the Maximum Correlation Method （MCM） was applied on the Infrared Astronomical Satellite （IRAS） data. The morphology of 13CO column density map shows a close correlation to that of 100μm dust optical depth. The distribution of the optical depth at 100 μm follows that of gas column density more closely than does the flux map at either 60 or 100μm. The ratio of the 13CO column density to the 100μm optical depth shows a decreasing trend with increasing dust optical depth in the central part, indicating possible molecular gas condensation onto dust particles. The excessive decrease in the CO column density in the envelope may most probably be due to the photo-dissociation of CO molecules.展开更多
The microstructure and mechanical properties of Mg-xCe-0.5Zn （x=0.5, 1.5, 2.5, molar fraction, %） alloys were examined using a nano-indentation technique. The alloys were fabricated using a vacuum induction melting ...The microstructure and mechanical properties of Mg-xCe-0.5Zn （x=0.5, 1.5, 2.5, molar fraction, %） alloys were examined using a nano-indentation technique. The alloys were fabricated using a vacuum induction melting method under an argon atmosphere The microstruetures of Mg-xCe-0.5Zn alloys mainly consist ofa-Mg and eutectic Mg12Ce phase. The volume fraction and size of the eutectic Mgl2Ce phase increase with increasing Ce contents. Nano-indentation test results show that the indentation hardness and elastic modulus of the eutectic Mg12Ce phase are higher than those of the a-Mg matrix. In addition, the mean indentation hardness and elastic modulus of the Mg-xCe-0.5Zn alloys increase with the Ce addition amount increasing.展开更多
Radial distribution of OH diffusion in silica glass preform during jacketing process using a oxy-hydrogen burner was investigated by FTIR spectroscopy. The OH peaks at the jacketing boundary and the surface of the pre...Radial distribution of OH diffusion in silica glass preform during jacketing process using a oxy-hydrogen burner was investigated by FTIR spectroscopy. The OH peaks at the jacketing boundary and the surface of the preform were found to be due to diffusion of OH incorporated from the burner.展开更多
AIM: To evaluate the serum levels of cytokeratins and carcinoembryonic antigen (CEA) in diagnosis, staging and prognosis of patients with colorectal adenocarcinoma.METHODS: The sample consisted of 169 patients. One hu...AIM: To evaluate the serum levels of cytokeratins and carcinoembryonic antigen (CEA) in diagnosis, staging and prognosis of patients with colorectal adenocarcinoma.METHODS: The sample consisted of 169 patients. One hundred blood donors formed the control group. Radical surgery was performed on 120 patients, with an average follow-up duration of 22.3 mo. Relapses occurred in 23individuals after an average of 18.09 mo. CEA was assayed via the Delfia(R) method with a limit of 5 ng/mL. Cytokeratins were assayed via the LIA-mat(R) TPA-M Prolifigen(R) method with a limit of 72 U/L.RESULTS: In the diagnosis of patients with colorectal adenocarcinoma, CEA showed a sensitivity of 56%, a specificity of 95%, a positive predictive value of 94%, a negative predictive value of 50% and an accuracy of 76.8%.TPA-M had a sensitivity of 70%, a specificity of 96%, a positive predictive value of 97%, a negative predictive value of 66% and an accuracy of 93.6%. The elevation of one of the markers was shown to have a sensitivity of 76.9%, a specificity of 91%, a positive predictive value of 93.5%, a negative predictive value of 70% and an accuracy of 83.6%.There was no variation in the levels of the markers according to the degree of cell differentiation while there was an elevation in their concentrations in accordance with the increase in neoplastic dissemination. There was a statistically significant difference between the patients with stage Ⅳ lesions and those with stages Ⅰ, Ⅱ and Ⅲ tumors.With regard to CEA, the averagelevel was 14.2 ng/mL in patients with stage Ⅰ lesions, 8.5 ng/mL in patients with stage Ⅱ lesions, 8.0 ng/mL in patients with stage Ⅲ lesions and 87.7 ng/mL in patients with stage Ⅳ lesions. In relation to TPA-M, the levels were 153.1 U/L in patients with stage Ⅰtumors, 106.5 U/L in patients with stage Ⅱ tumors, 136.3 U/L in patients with stage Ⅲ tumors and 464.3 U/L in patients with stage Ⅳ tumors. There was a statistical difference in patients with a high CEA level in relation to a shorter展开更多
Glioblastoma(GBM),the deadliest form of brain cancer,presents long-standing problems due to its localization.Chimeric antigen receptor(CAR)T cell immunotherapy has emerged as a powerful strategy to treat cancer.IL-13-...Glioblastoma(GBM),the deadliest form of brain cancer,presents long-standing problems due to its localization.Chimeric antigen receptor(CAR)T cell immunotherapy has emerged as a powerful strategy to treat cancer.IL-13-receptor-α2(IL13Rα2),present in over 75%of GBMs,has been recognized as an attractive candidate for antiglioblastoma therapy.Here,we propose a novel multidisciplinary approach to target brain tumors using a combination of fluorescent,therapeutic nanoparticles and CAR T cells modified with a targeted-quadruplemutant of IL13(TQM-13)shown to have high binding affinity to IL13Rα2-expressing glioblastoma cells with low off-target toxicity.Azide-alkyne cycloaddition conjugation of nanoparticles to the surface of T cells allowed a facile,selective,and high-yielding clicking of the nanoparticles.Nanoparticles clicked onto T cells were retained for at least 8 days showing that the linkage is stable and promising a suitable time window for in vivo delivery.T cells clicked with doxorubicin-loaded nanoparticles showed a higher cytotoxic effect in vitro compared to bare T cells.In vitro and in vivo T cells expressing TQM-13 served as delivery shuttles for nanoparticles and significantly increased the number of nanoparticles reaching brain tumors compared to nanoparticles alone.This work represents a new platform to allow the delivery of therapeutic nanoparticles and T cells to solid tumors.展开更多
基金the support from the National Natural Science Foundation of China(No.51171033)the Fundamental Research Funds for the Central Universities(DUT15LAB05,DUT16LAB03)
文摘The microwave absorbents of Fe and C nanoparticles as magnetic loss and dielectric loss material respectively were composited with the polyvinyl alcohol （PVA） as binder by spray granulation method, The electromagnetic parameters of Fe and C composite particles were analyzed by vector network. The complex permittivity and magnetic permeability of Fe and C composite particles matched well with increasing C nanoparticle content, and then the microwave loss property was improved. A minimum reflection loss （RL） of -42.7 dB at 3.68 GHz for a composite with 4.6 mm in thickness can be obtained when the content ratio of the C nanoparticles, the modified Fe nanoparticles and the PVA is 21：49：30 （Sample 3）.
文摘The heat transfer enhancement characteristics of water with polystyrene particles are examined in the present numerical study. The numerical study is conducted in the hydrodynamically fully developed turbulent flows within a circular duct with the wall boundary condition of a constant heat flux. The thermal conductivity of the turbulent flow obtained by the Reynolds analogy is 1000 times as much as the thermal conductivity of water. On the contrary, the enhancement of thermal conductivity caused by water-microparticles suspension is relatively low. Slight enhancements of the local Nusselt number are obtained in the numerical calculations of Newtonian turbulent flows with the micro-convection effects, thus showing large deviations from the experimental data. The numerical results in non-Newtonian flows are in agreement with the experimental data. Thus, the main cause for the enhancement of the heat transfer of the suspension might be not due to the micro-convection effects but to the non-Newtonian
基金supported by the following funding sources:Science Committee of the Republic of Armenia Grant No.18T-1C180Australian Research Council and research grant Nos.DP180102629,DP170102389,DP170102204,DP150103061,FT130100303,and FT130100018+22 种基金Austrian Federal Ministry of Education,Science and Research,and Austrian Science Fund No.P 31361-N36Natural Sciences and Engineering Research Council of Canada,Compute Canada and CANARIEChinese Academy of Sciences and research grant No.QYZDJ-SSW-SLH011National Natural Science Foundation of China and research grant Nos.11521505,11575017,11675166,11761141009,11705209,and 11975076LiaoNing Revitalization Talents Program under contract No.XLYC1807135Shanghai Municipal Science and Technology Committee under contract No.19ZR1403000Shanghai Pujiang Program under Grant No.18PJ1401000the CAS Center for Excellence in Particle Physics(CCEPP)the Ministry of Education,Youth and Sports of the Czech Republic under Contract No.LTT17020Charles University grants SVV260448 and GAUK 404316European Research Council,7th Framework PIEF-GA-2013-622527Horizon 2020 Marie Sklodowska-Curie grant agreement No.700525’NIOBE,’Horizon 2020 Marie Sklodowska-Curie RISE project JENNIFER grant agreement No.644294Horizon 2020 ERC-Advanced Grant No.267104NewAve No.638528(European grants)L’Institut National de Physique Nucléaire et de Physique des Particules(IN2P3)du CNRS(France),BMBF,DFG,HGF,MPG and AvH Foundation(Germany)Department of Atomic Energy and Department of Science and Technology(India)Israel Science Foundation grant No.2476/17United States-Israel Binational Science Foundation grant No.2016113Istituto Nazionale di Fisica Nucleare and the research grants BELLE2Japan Society for the Promotion of Science,Grant-in-Aid for Scientific Research grant Nos.16H03968,16H03993,16H06492,16K05323,17H01133,17H05405,18K03621,18H03710,18H05226,19H00682,26220706,and 26400255the National Institute of Informatics,and Science Information NETwork 5(SINET5)the Ministry of Education,Culture,Sports,Science,an
文摘From April to July 2018,a data sample at the peak energy of the T(4 S) resonance was collected with the Belle Ⅱ detector at the SuperKEKB electron-positron collider.This is the first data sample of the Belle Ⅱ experiment.Using Bhabha and digamma events,we measure the integrated luminosity of the data sample to be(496.3±0.3±3.0) pb-1,where the first uncertainty is statistical and the second is systematic.This work provides a basis for future luminosity measurements at Belle Ⅱ.
文摘The isotope ratio mass spectrometer (IRMS) is an instrument that measures both of the elemental contents and isotope ratios of hydrogen, oxygen, carbon, nitrogen and sulfur in environmental samples at the same time. In this study, we want to try to get two main goals;first, to make up for setting the analytical conditions such as accuracy and precision, second, to apply for comparing of the carbon and nitrogen isotope ratio of sediments in the abandoned mine located in middle province of Korea. For the first goal, a recently introduced IRMS was used to analyze CRM (certified reference materials), which helped to make up the analytical conditions of carbon and nitrogen isotope ratios. So, the accuracy and precision of isotope ratios and elemental contents were also assessed simultaneously, and also the results were very satisfactory. The analytical results of carbon reference materials (EMA-P2) showed an accuracy of -2.801 × 10‰ ± 0.01‰ (2σ) and a precision of 0.009‰ in the mass range from 0.008 μg - 0.162 μg. For nitrogen reference materials (EMA-P2), an accuracy of -1.632‰ ± 0.72‰ (2σ) was obtained in the mass range from 0.082 - 0.162 mg. These values of accuracy and precision are higher than those reported by other studies. For the second goal, carbon and nitrogen isotopes in river sediment near abandoned mines were analyzed based on the established analytical conditions. The result suggested that carbon isotope ratios ranged from -22.5‰ - -7.5‰ and nitrogen isotope ratios from -1.9‰ - 7.9‰. By comparing the isotope ratios and sampling sites of sediment, we know that the nitrogen isotope values in samples of entrance area of mine are greater than those of the farm house area, which is indicating the effects of organic materials. So, we could guess that the newly accumulated organic materials were much more in the farm house area than mine entrance area. And a result of this study, the accuracy and precision tests of IRMS using certified reference materials were very satisfactory and opt
基金supported by a grant from the Ministry of Knowledge Economy,Republic of Koreaby NCRC (National Core Research Center) Program through the National Research Foundation of Korea funded by the Ministry of Education,Science and Technology (2010-0001-222)
文摘For Al 6k21-T4 overlap weld joint,the shear-tensile strength by using the weaving laser was improved as compared to the case of linear laser.For the specimen of low strength,the porosity was distributed continuously along the intersection between the plates and fusion line.However,for the optimized welding condition,large oval-shaped porosities were located only in the advancing track of the concave part.Therefore,the continuity of cracks and porosities played a key role to determine the strength.And,the weaving width was also the important parameter to control the strength.Furthermore,the concave part had more significant hot and cold cracking in the weld and heat-affected zone（HAZ）,respectively,than the convex part.
基金supported by a grant from the Metals Bank by the Ministry of Knowledge Economy and a grant-in-aid for the National Core Research Center Program (No.R15-2006-022-02001-0)
文摘The effects of Ca and Sr addition on the microstructure and creep properties of Mg-4Al-2Sn alloys were examined. Tensile tests at 25 ℃ and 200 ℃ and creep tests at 150 ℃ and 200 ℃ were carried out to estimate the room temperature and high temperature mechanical properties of these alloys. The microstrueture of the Mg-4Al-2Sn alloy showed dendritic a-Mg, Mg17Al12 and Mg2Sn phases. The latter two phases precipitated along the grain boundaries. The addition of Ca and Sr resulted in the formation of ternary CaMgSn and SrMgSn phases within the grain. The grain size was reduced slightly with the addition of Sr and Ca. The tensile strength was decreased by the addition of Ca and Sr at room temperature. However, the high temperature tensile strength was increased. The creep strength was improved by the addition of Ca and Sr.
文摘The effects of Si content on combinations of important properties such as hardness, hardenability, and weldability in addition to strength increment were systematically investigated to develop a Mo and V free low alloy cast steel for automobile cold pressing die insert. For the evaluation of the applicability as the die insert, the mechanical properties were measured after spheroidization annealing （SA）, quenching and tempering （Q/T）, and flame hardening （FH） treatments, respectively. The developed 0.8%-1.6%Si containing Mo and V free alloy cast steels showed excellent matrix strengthening effect, hardenability, and weldability, fulfilling the industrial criterion of the mechanical properties for the die insert.
基金the National Natural Science Foundatlon of China under projects 59725103 ,50171070.
文摘Nanoparticles of Fe-Co alloys and their oxides with the particle size below 20 nm were prepared by chemical vapor condensation process. The pure Ar, Ar+1%O2, Ar+3%O2 and Ar+6%O2 were used as carrier gases, with iron carbonyl and cobalt carbonyl as the precursors. XRD patterns showed that Fe-Co metallic nanoparticles were synthesized by using pure Ar as carrier gas, and only metal oxides were obtained using Ar+(>3)%O2 as carrier gas. The HRTEM images and TG-DTA curves were used to study the core-shell structure of the different nanoparticles. The nanoparticles obtained in pure Ar consist of black core and light shell with thickness of 2~4 nm. However, in the particles obtained in Ar+6%02, the oxides core with visible lattice fringes are surrounded by thin shell.
基金the Korean Ministry of Science and Technology under the KSTAR project contract
文摘As there is substantial progress in the KSTAR tokamak engineering, all themajor structures and sub-systems are under fabrication and in procurement phase. The vacuum vessel,port, cryostat cylinder, lid, and bellows are being rigorously fabricated in the factory. The lowerpart of the KSTAR such as cryostat base and gravity support has been almost finished in itsfabrication. There are also great progresses and significant results in manufacturing of thesuperconducting magnet, including four Toroidal Field (TF) coils, lower and upper PF7 coils whichare the largest Poloidal Field (PF) coils. The TFOO coil, which has been made for test and back-upof the TF magnet system, was successfully tested in the cool-down and current charging. As thefabrications and procurements of major structures have been actively proceeded, assembly works werealso launched from Aug. 2003. More detailed description on these status, results, and plans will bedescribed in this paper.
文摘Correlation between gas and dust column density has been studied for the dark globule L1523. The 13CO（J=1→0） emission is used for tracing the gas, and the IR emissions, for tracing the dust constituent. In order to match the beam resolution between the images, a beam de-convolution algorithm based on the Maximum Correlation Method （MCM） was applied on the Infrared Astronomical Satellite （IRAS） data. The morphology of 13CO column density map shows a close correlation to that of 100μm dust optical depth. The distribution of the optical depth at 100 μm follows that of gas column density more closely than does the flux map at either 60 or 100μm. The ratio of the 13CO column density to the 100μm optical depth shows a decreasing trend with increasing dust optical depth in the central part, indicating possible molecular gas condensation onto dust particles. The excessive decrease in the CO column density in the envelope may most probably be due to the photo-dissociation of CO molecules.
基金supported by a grant-in-aid for the National Core Research Center Program(No.R15-2006-022-02001-0)the Metals Bank project of the Korea Ministry of Knowledge Economy
文摘The microstructure and mechanical properties of Mg-xCe-0.5Zn （x=0.5, 1.5, 2.5, molar fraction, %） alloys were examined using a nano-indentation technique. The alloys were fabricated using a vacuum induction melting method under an argon atmosphere The microstruetures of Mg-xCe-0.5Zn alloys mainly consist ofa-Mg and eutectic Mg12Ce phase. The volume fraction and size of the eutectic Mgl2Ce phase increase with increasing Ce contents. Nano-indentation test results show that the indentation hardness and elastic modulus of the eutectic Mg12Ce phase are higher than those of the a-Mg matrix. In addition, the mean indentation hardness and elastic modulus of the Mg-xCe-0.5Zn alloys increase with the Ce addition amount increasing.
文摘Radial distribution of OH diffusion in silica glass preform during jacketing process using a oxy-hydrogen burner was investigated by FTIR spectroscopy. The OH peaks at the jacketing boundary and the surface of the preform were found to be due to diffusion of OH incorporated from the burner.
基金Supported by Foundation for Research Support of the State of Sao Paulo
文摘AIM: To evaluate the serum levels of cytokeratins and carcinoembryonic antigen (CEA) in diagnosis, staging and prognosis of patients with colorectal adenocarcinoma.METHODS: The sample consisted of 169 patients. One hundred blood donors formed the control group. Radical surgery was performed on 120 patients, with an average follow-up duration of 22.3 mo. Relapses occurred in 23individuals after an average of 18.09 mo. CEA was assayed via the Delfia(R) method with a limit of 5 ng/mL. Cytokeratins were assayed via the LIA-mat(R) TPA-M Prolifigen(R) method with a limit of 72 U/L.RESULTS: In the diagnosis of patients with colorectal adenocarcinoma, CEA showed a sensitivity of 56%, a specificity of 95%, a positive predictive value of 94%, a negative predictive value of 50% and an accuracy of 76.8%.TPA-M had a sensitivity of 70%, a specificity of 96%, a positive predictive value of 97%, a negative predictive value of 66% and an accuracy of 93.6%. The elevation of one of the markers was shown to have a sensitivity of 76.9%, a specificity of 91%, a positive predictive value of 93.5%, a negative predictive value of 70% and an accuracy of 83.6%.There was no variation in the levels of the markers according to the degree of cell differentiation while there was an elevation in their concentrations in accordance with the increase in neoplastic dissemination. There was a statistically significant difference between the patients with stage Ⅳ lesions and those with stages Ⅰ, Ⅱ and Ⅲ tumors.With regard to CEA, the averagelevel was 14.2 ng/mL in patients with stage Ⅰ lesions, 8.5 ng/mL in patients with stage Ⅱ lesions, 8.0 ng/mL in patients with stage Ⅲ lesions and 87.7 ng/mL in patients with stage Ⅳ lesions. In relation to TPA-M, the levels were 153.1 U/L in patients with stage Ⅰtumors, 106.5 U/L in patients with stage Ⅱ tumors, 136.3 U/L in patients with stage Ⅲ tumors and 464.3 U/L in patients with stage Ⅳ tumors. There was a statistical difference in patients with a high CEA level in relation to a shorter
基金supported in part by PA Tobacco Settlement Fund(Grant 4100062216,to C.D.,J.Y.J.C)support from the National Institutes of Health Award(AR072731,to J.Y.and EB026035,to X.L.)the National Science Foundation(NSF)Award(CBET-BME1330663,to C.D.)。
文摘Glioblastoma(GBM),the deadliest form of brain cancer,presents long-standing problems due to its localization.Chimeric antigen receptor(CAR)T cell immunotherapy has emerged as a powerful strategy to treat cancer.IL-13-receptor-α2(IL13Rα2),present in over 75%of GBMs,has been recognized as an attractive candidate for antiglioblastoma therapy.Here,we propose a novel multidisciplinary approach to target brain tumors using a combination of fluorescent,therapeutic nanoparticles and CAR T cells modified with a targeted-quadruplemutant of IL13(TQM-13)shown to have high binding affinity to IL13Rα2-expressing glioblastoma cells with low off-target toxicity.Azide-alkyne cycloaddition conjugation of nanoparticles to the surface of T cells allowed a facile,selective,and high-yielding clicking of the nanoparticles.Nanoparticles clicked onto T cells were retained for at least 8 days showing that the linkage is stable and promising a suitable time window for in vivo delivery.T cells clicked with doxorubicin-loaded nanoparticles showed a higher cytotoxic effect in vitro compared to bare T cells.In vitro and in vivo T cells expressing TQM-13 served as delivery shuttles for nanoparticles and significantly increased the number of nanoparticles reaching brain tumors compared to nanoparticles alone.This work represents a new platform to allow the delivery of therapeutic nanoparticles and T cells to solid tumors.
