Background It is unclear whether the efficacy of single prophylactic antibiotic administration has an impact on infection and death in patients with Aortic Dissection of Stanford B treated by Endovascular Aortic Repa...Background It is unclear whether the efficacy of single prophylactic antibiotic administration has an impact on infection and death in patients with Aortic Dissection of Stanford B treated by Endovascular Aortic Repair （EVAR）. Methods According to whether or not received antibiotics prophylaxis, patients were divided into two groups： the single prophylactic antibiotic group （Group A） and non-prophylactic antibiotic group （Group B）. Procalcitonin （PCT） and other clinical data were obtained with follow-up for one year. Results A total of 201 patients were screened. Among which, 70 patients received single antibiotic administration and 131 patients did not. 31（44.3%） patients had fever in group A while 81（61.8%） patients had fever in group B after EVAR （P=0.017）. The PCT and C-reactive protein （CRP） were significantly different between the two group： 0.18 ± 0.31 vs. 0.76 ± 1.18（ng/mL） （P=0. 000）, 81.35 ± 31.83 vs. 105.02 ± 60.37（mg/mL） （P=0.000）, respectively. By comparison of incidences of postoperative infection, 4（5.7%） patients were infected in Group A while 26（19.8%） patients were infected in Group B （P=0.007）. In infected group, the PCT in group A was 1.04±0.82 while that in Group B was 2.67±1.28 （P=0.015）. In non-infected group, the PCT in group A was 0.12±0.14 while that in Group B was 0.29± 0.44 （P=0.005）. Finally, One-year mortality in group A was 2（2.9%） while that in Group B （P=0.037） was 15 （11.5%）. Conclusion Single prophylactic antibiotic administration can significantly reduce the incidences of postoperative infection and affect the prognosis after EVAR.展开更多
基金supported by Medical Research Foundation of Guangdong Province(No.A2014060)Medical Research Foundation of Kashgar(No.2015Y02)Technology Project of Kashgar region's first people's hospital(No.105)
文摘Background It is unclear whether the efficacy of single prophylactic antibiotic administration has an impact on infection and death in patients with Aortic Dissection of Stanford B treated by Endovascular Aortic Repair （EVAR）. Methods According to whether or not received antibiotics prophylaxis, patients were divided into two groups： the single prophylactic antibiotic group （Group A） and non-prophylactic antibiotic group （Group B）. Procalcitonin （PCT） and other clinical data were obtained with follow-up for one year. Results A total of 201 patients were screened. Among which, 70 patients received single antibiotic administration and 131 patients did not. 31（44.3%） patients had fever in group A while 81（61.8%） patients had fever in group B after EVAR （P=0.017）. The PCT and C-reactive protein （CRP） were significantly different between the two group： 0.18 ± 0.31 vs. 0.76 ± 1.18（ng/mL） （P=0. 000）, 81.35 ± 31.83 vs. 105.02 ± 60.37（mg/mL） （P=0.000）, respectively. By comparison of incidences of postoperative infection, 4（5.7%） patients were infected in Group A while 26（19.8%） patients were infected in Group B （P=0.007）. In infected group, the PCT in group A was 1.04±0.82 while that in Group B was 2.67±1.28 （P=0.015）. In non-infected group, the PCT in group A was 0.12±0.14 while that in Group B was 0.29± 0.44 （P=0.005）. Finally, One-year mortality in group A was 2（2.9%） while that in Group B （P=0.037） was 15 （11.5%）. Conclusion Single prophylactic antibiotic administration can significantly reduce the incidences of postoperative infection and affect the prognosis after EVAR.
