摘要
<span style="font-family:;" "=""><strong>Introduction</strong>:</span><span><span><span style="font-family:;" "=""> <i>Momordica charantia</i> (MC) has been reported to possess various beneficial effects. Improvement in natural aging of the skin has been observed with the use of MC. However, few studies have detailed the effects of MC on atopic dermatitis (AD). Therefore, in this study, we investigated the effects of MC on the skin symptoms of AD. <b>Methods:</b> Specific pathogen-free <span>and conventional NC/Nga mice were orally administered a 50 mg/kg/day</span> dose of MC every day for 2 weeks. <b>Results:</b> The expression levels of lipopolysaccharide (LPS), inducible nitric oxidase synthase (iNOS), and prostaglandin E2 (PGE2) remarkably increased in AD, but were suppressed by MC administration. As a result, the degradation of filaggrin by PGE2 was suppressed. Furthermore, in AD, iNOS induced macrophage type 1 and increased NO levels. <span>In contrast, due to suppression of iNOS with MC administration, macro</span><span>phages shifted to type 2 and an increase in L-ornithine was observed, which</span> subsequently promoted filaggrin synthesis. <b>Conclusions:</b> </span></span></span><span><span><span style="font-family:;" "="">These findings indicate that the AD-like skin symptoms were decelerated by MC via the regu<span>lation of the LPS/iNOS/PGE2/filaggrin and LPS/iNOS/Arginase 1/L-ornithine/ </span>filaggrin signaling pathways.</span></span></span>
<span style="font-family:;" "=""><strong>Introduction</strong>:</span><span><span><span style="font-family:;" "=""> <i>Momordica charantia</i> (MC) has been reported to possess various beneficial effects. Improvement in natural aging of the skin has been observed with the use of MC. However, few studies have detailed the effects of MC on atopic dermatitis (AD). Therefore, in this study, we investigated the effects of MC on the skin symptoms of AD. <b>Methods:</b> Specific pathogen-free <span>and conventional NC/Nga mice were orally administered a 50 mg/kg/day</span> dose of MC every day for 2 weeks. <b>Results:</b> The expression levels of lipopolysaccharide (LPS), inducible nitric oxidase synthase (iNOS), and prostaglandin E2 (PGE2) remarkably increased in AD, but were suppressed by MC administration. As a result, the degradation of filaggrin by PGE2 was suppressed. Furthermore, in AD, iNOS induced macrophage type 1 and increased NO levels. <span>In contrast, due to suppression of iNOS with MC administration, macro</span><span>phages shifted to type 2 and an increase in L-ornithine was observed, which</span> subsequently promoted filaggrin synthesis. <b>Conclusions:</b> </span></span></span><span><span><span style="font-family:;" "="">These findings indicate that the AD-like skin symptoms were decelerated by MC via the regu<span>lation of the LPS/iNOS/PGE2/filaggrin and LPS/iNOS/Arginase 1/L-ornithine/ </span>filaggrin signaling pathways.</span></span></span>
作者
Keiichi Hiramoto
Kumi Orita
Yurika Yamate
Hiromi Kobayashi
Keiichi Hiramoto;Kumi Orita;Yurika Yamate;Hiromi Kobayashi(Department of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka, Japan;Department of Orthopedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan;Kobayashi Dermatology Clinic, Nishinomiya, Japan)
