摘要
目的:米非司酮在腹腔镜下子宫肌瘤剔除术后复发中的作用。方法:本研究选择自2021年1月至2022年1月收入我院妇科的132例符合条件的子宫肌瘤患者为研究对象,所有入组的子宫肌瘤患者均选择腹腔镜下子宫肌瘤剔除术,根据是否用米非司酮进行治疗,将入组的132例患者分成2组,即米非司酮组和对照组,其中米非司酮组患者包括69例,对照组包括63例,术后进行对症处理,不采用米非司酮治疗。统计并记录术后12周血清的卵泡刺激素(Follicle Stimulating Hormone, FSH),促黄体生成素(Luteinizing Hormone, LH),雌激素(Estrogen 2, E2)和孕酮(Progesterone, P)含量,术后24月的子宫肌瘤复发率。结果:术后12周米非司酮组患者的卵泡刺激素(FSH),促黄体生成素(LH),雌激素(E2)和孕酮(P)水平要明显低于对照组(P < 0.05)。术后24月内,对照组患者中共有12例患者复发,复发率为19.05%,米非司酮组者中共有6例患者复发,复发率为8.70%,比较具有统计学差异(P < 0.05)。结论:米非司酮可以降低腹腔镜下子宫肌瘤剔除术后复发率,值得临床上推广和应用。
Objective: To investigate the effect of mifepristone on recurrence after laparoscopic myomectomy. Methods: The 132 eligible patients with hysteromyoma admitted to the Department of Gynecology of our hospital from January 2021 to January 2022 were selected as the research object. All patients with hysteromyoma were selected for laparoscopic hysteromyomectomy. According to whether they were treated with mifepristone or not, 132 patients were divided into two groups, namely mifepristone group and control group, including 69 patients in mifepristone group and 63 patients in control group, symptomatic treatment was performed after operation, and mifepristone was not used. The serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), estrogen (E2) and progesterone (P) at 12 weeks after operation and the recurrence rate of hysteromyoma at 24 months after operation were counted and recorded. Results: The levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), estrogen (E2) and progesterone (P) in mifepristone group were significantly lower than those in control group 12 weeks after operation (P < 0.05). Within 24 months after operation, 12 patients in the control group recurred, with a recurrence rate of 19.05%, and 6 patients in the mifepristone group recurred, with a recurrence rate of 8.70% (P < 0.05). Conclusion: The mifepristone can reduce the recurrence rate after laparoscopic myomectomy, which is worthy of clinical promotion and application.
出处
《医学诊断》
2022年第2期167-171,共5页
Medical Diagnosis
