摘要
近年来,动脉粥样硬化作为一种慢性炎症性血管疾病对人类生命产生严重威胁因而成为当代研究热点之一,其发生主要是由于动脉内脂质沉积纤维斑块形成,内皮细胞巨噬细胞等炎性细胞功能障碍导致血管壁硬化血栓形成。与此同时,内皮细胞功能障碍被认为是动脉粥样硬化损伤的始动因素,内皮细胞死亡促炎因子被大量释放加速动脉粥样硬化发展进程。细胞焦亡是近年来细胞死亡方向的研究热点之一,在动脉粥样硬化研究进展中内皮细胞焦亡便是最新热点之一。中药单体或单体有效活性成分都通过发挥自身多靶点、多疗效优势在治疗动脉粥样硬化方面取得了不菲成绩。
In recent years, atherosclerosis, as a chronic inflammatory vascular disease, has increasingly be-come one of the hot spots in contemporary research because of its serious threat to human life. Its occurrence is mainly due to the dysfunction of inflammatory cells such as lipid deposition in arter-ies, fibrous plaque formation and endothelial macrophages, which leads to the formation of vascular wall sclerosis and thrombosis. At the same time, endothelial dysfunction is considered to be the ini-tial factor of atherosclerosis injury, and endothelial cell death pro-inflammatory factors are released in large quantities to accelerate the development of atherosclerosis. Cell apoptosis is one of the re-search hotspots in the direction of cell death in recent years, and endothelial cell pyroptosis has gradually become one of the research hotspots of atherosclerosis. Traditional Chinese medicine monomer and monomer active components have made great achievements in the treatment of atherosclerosis by giving full play to their multi-target and multi-therapeutic advantages.
出处
《临床医学进展》
2024年第2期2301-2307,共7页
Advances in Clinical Medicine
