摘要
肺大细胞神经内分泌肿瘤(Large cell neuroendocrine lung cancer, LCNEC)是一种来源于支气管黏膜Kulchitsky细胞的恶性肿瘤,临床发病率比较少见,肺神经内分泌肿瘤占所有肺肿瘤的15%~20%,Jiang等报道766例接受手术的肺癌患者中,其中22例为LCNEC。LCNEC更常见于外周肿瘤,少数可位于中心位置。大部分患者出现的临床表现与常见肺部肿瘤相似,影像学诊断缺乏特异性,随着免疫组织化学的发展,近年来更多肿瘤患者被确诊。由于恶性程度高,早期诊断并以手术为主的综合治疗为首选治疗方式。
Large cell neuroendocrine lung cancer (LCNEC) is a malignant tumor originated from bronchial mu-cosa Kulchitsky cells, with a relatively rare clinical incidence. Lung neuroendocrine tumors account for 15%~20% of all lung tumors. Jiang et al. reported that among 766 lung cancer patients who un-derwent surgery, 22 cases were LCNEC. LCNEC is more common in peripheral tumors, and a few may be centrally located. The clinical manifestations of most patients are similar to common lung tumors, and imaging diagnosis lacks specificity. With the development of immunohistochemistry, more pa-tients with tumors have been diagnosed in recent years. Due to the high degree of malignancy, early diagnosis combined with surgery is the preferred treatment.
出处
《临床医学进展》
2022年第5期4166-4171,共6页
Advances in Clinical Medicine
