摘要
胃癌(gastric cancer, GC)是消化道常见肿瘤之一,早期诊断率低,多数患者出现临床症状就诊往往是GC发展的晚期,因此治疗效果不佳,转移风险高,预后差。近年国内外多个研究证实组蛋白去乙酰化酶(histone deacetylases, HDACs)在肿瘤进展中起着关键作用,通过改变组蛋白和非组蛋白的乙酰化来调控细胞周期、分化和凋亡,从而在肿瘤进展过程中破坏体内乙酰化动态平衡。GC的发生发展与HDACs表达失衡密切相关,然而它们在GC中的具体机制尚不清楚,本文主要对HDACs与GC的研究进行回顾和总结,以期为进一步研究提供参考,为临床治疗提供新作用靶点。
Gastric cancer (GC) is one of the common malignant gastrointestinal tumors, with low early diagnosis rate. Most patients presenting clinical symptoms tend to be at the late stage of GC development, so this leads to a low cure rate, a high risk of metastasis, and a poor prognosis. In recent years, many researches in the domestic and foreign have confirmed that histone deacetylases (HDACs) play a critical role in tumor progression. HDACs regulate cell cycle, differentiation and apoptosis by changing the acetylation of histones and non-histones, thus disrupting the dynamic balance of acetylation in vivo during tumor progression. The occurrence and development of GC are closely related to the imbalance of HDACs expression. However, the specific role of HDACs in GC is still unclear. This article mainly reviews and summarizes the research on HDACs and GC, so as to provide reference for further research and provide a new target for clinical treatment.
出处
《临床医学进展》
2020年第9期2127-2132,共6页
Advances in Clinical Medicine
