摘要
肿瘤坏死因子-α(TNF-α)是最主要的促炎症细胞因子之一,主要是由激活的单核/巨噬细胞分泌,在炎症、免疫调节反应、细胞生长、细胞凋亡中起重要作用。左心室重构可导致心肌病进行性发展,甚至引起恶性心律失常、心力衰竭及心源性猝死的发生,其进展过程中与肿瘤坏死因子-α(TNF-α)密切相关,肿瘤坏死因子-α(TNF-α)的研究可帮助临床医师及早识别无临床症状患者心室重构的发生,且通过抗肿瘤坏死因子-α(TNF-α)的治疗对延缓心室重构及改善患者预后发挥着重要作用。本文就肿瘤坏死因子- α(TNF-α)与左心室重构关系的最新研究进展进行综述。
Tumor necrosis factor alpha (TNF-alpha) is one of the most potent pro-inflammatory cytokines, which is mainly secreted by activated monocytes/macrophages and plays an important role in in-flammation, immunoregulation, cell growth and apoptosis. Left ventricular remodeling can lead to progressive cardiomyopathy, and even cause malignant arrhythmia, heart failure and sudden car-diac death;TNF-alpha is closely related to the progress of left ventricular remodeling. The research of TNF-alpha may help clinical physicians to identify patients with no clinical evidence of ventricular remodeling, and anti-TNF may play a significant role in delaying the progress of ventricular remodeling and improving the prognosis of patients. This paper makes a review of the recent research progress on the correlation between TNF-alpha and left ventricular remodeling.
出处
《临床医学进展》
2017年第1期6-10,共5页
Advances in Clinical Medicine
