摘要
目的比较氟西汀与地西泮治疗广泛性焦虑症的临床疗效和不良反应。方法对 112例符合CCMD 3诊断标准的广泛性焦虑症患者 ,随机分为两组 ,分别应用氟西汀 ( 5 6例 )、地西泮 ( 5 6例 )治疗 4周。采用焦虑自评量表 (SAS)、汉密顿焦虑量表 (HAMA)和副反应量表 (TESS)评定疗效和副反应。结果氟西汀与地西泮对广泛性焦虑症均有显著疗效 ,两组间无显著性差异 (P >0 .0 5 )。治疗第 4周末两组SAS、HAMA以及HAMA因子分的减分前后比较差异有显著性 (P <0 .0 1) ,氟西汀不良反应明显少于地西泮 ,TESS氟西汀组为 4.0 6± 1.47,地西泮组为 6.0 4± 2 .2 9(P <0 .0 1)。结论氟西汀治疗广泛性焦虑症安全有效 ,副作用少。
ObjectiveTo compare the efficacy and side effects of fluoxetine and diazepam in treatment of generalized anxiety disorder. Methods112 patients who met with the criteria of CCMD-3 for generalized anxiety disorder were randomly assigned to fluoxetine and diazepam treatment for 4 weeks. Efficacy and side effects were assessed by HAMA, SAS and TESS.Results Both drugs had marked efficacy in treatment of generalized anxiety disorder, but there was not significant difference between two groups (P>0.05). Two groups showed marked improvement in scores of SAS and HAMA (P<0.01). Fluoxetine had fewer side effects than diazepam. Conclusion Fluoxetine is a safe and efficient drug for the treatment of generalized anxiety disorder.
出处
《中国行为医学科学》
CSCD
2004年第3期282-283,共2页
Chinese Journal of Behavioral Medical Science
