摘要
目的:探讨帕罗西汀联合放松训练治疗广泛性焦虑的疗效及安全性。方法:将60例广泛焦虑患者随机分为研究组(n=30)和对照组(n=30),分别给予帕罗西汀联合放松训练和帕罗西汀治疗,药物治疗剂量均为20～40 mg/d,疗程6周。治疗前后分别用Hamilton焦虑量表(HAMA)及治疗中出现的症状量表(TESS)评定疗效及不良反应。结果:与治疗前相比,治疗2周末两组HAMA评分均显著下降(P<0.01),研究组精神、躯体焦虑因子分下降明显(P<0.05),对照组精神因子分于2周末、躯体焦虑因子分于6周末差异有显著性(P<0.05);两组间比较,治疗2、4、6周末HAMA评分差异均有显著性(P均<0.05),精神、躯体焦虑因子分差异不显著。研究组有效率为87.5%,对照组为85.0%,两组疗效无显著性差异(P>0.05)。研究组第1周末即显效,不良反应较对照组少且轻微。结论:帕罗西汀联合放松训练治疗广泛性焦虑起效快、依从性好,是一种安全、有效的治疗方法。
Objective:To investigate the clinical efficacy and adverse of paroxetine combined with relaxation training in the treatment of generalized anxiety disorder.Methods:60 patients with generalized anxiety disorder were randomly divided into study groups(n=30) and control groups(n=30).Study groupa were treated with paroxetine combined with relaxation training and control groups were given paroxetine singly for 6 weeks.Hamilton Anxiety Scale (HAMA) was adopted to evaluate the efficacy.Safety was evaluated by Treatment Emergent Symptom Scale (TESS).Results:Compared with before treatment,the total scores of HAMA in two groups significantly decreased after two weeks treatment(P < 0.01).The scores of psychotic anxiety gene and somatic anxiety gene in study groups decreased remarkably and there were significant differences in the scores of somatic anxiety gene in control group at 6 weekend (P < 0.05).There were significant differences in the scores of HAMA between two groups after treatment(P < 0.05).The effective rate of study group was 87.5% and control group was 85.0%.There were some significant differences between the two groups (P < 0.05) o However the adverse reactions of study group was lower and lighter than control group.Conclusions:paroxetine combined with relaxation training is an effective and safe method in the treatment of generalized anxiety disorder with good tolerance and compliance.
出处
《中国民康医学》
2009年第21期2679-2681,共3页
Medical Journal of Chinese People’s Health
关键词
帕罗西汀
放松训练
广泛性焦虑
效果评价
Paroxetine
Relaxation training
Generalized anxiety disorder
Effective evaluation
