摘要
目的 :观察刺五加叶皂苷 (ASS)对实验性脑缺血大鼠血液流变学及血小板功能的影响。方法 :大鼠连续腹腔注射 ASS 2 5、 5 0和 1 0 0 mg· kg- 1 3d后 ,结扎双侧颈总动脉伴低血压制作实验性脑缺血模型 ,1 5 m in后测定大鼠血液流变学各参数、血小板粘附及聚集功能等指标。结果 :ASS 5 0、 1 0 0 mg· kg- 1 均能明显降低实验性脑缺血大鼠全血粘度、血浆粘度、血浆纤维蛋白原浓度、血沉、红细胞压积、红细胞聚集指数、红细胞刚性指数及抑制血小板粘附、聚集功能 (P<0 .0 5～ P<0 .0 0 1 )。结论
Objective To observe the effects of Acanthopanax senticosus saponins (ASS) on hemorrheology and platelet function in experimental cerebral ischemia rats. Methods The cerebral ischemia model induced by bilateral common carotid artery clamping and controlled hemorrhage to a mean arterial pressure of 50 mmHg was produced in rats treated by continuous intraperitoneal injection of ASS with dosages of 25,50,100 mg·kg -1 for 3 days. The effects of ASS on the hemorrheology and platelet aggregation and adhesion functions were measured after 15 min. Results ASS with dosages of 50 and 100 mg·kg -1 decreased the blood viscosity,plasma viscosity, plasma fibrinogen concentration,erythrocyte sedimentation,hematocrit, erythrocyte aggregation index, and erythrocyte rigidity index markedly,and inhibited platelet aggregation and adhesion functions. Conclusion ASS can improve evidently abnormal changes of hemorrheology and platelet functions in experimental cerebral ischemia rats.
出处
《吉林大学学报（医学版）》
CAS
CSCD
北大核心
2004年第3期384-386,共3页
Journal of Jilin University：Medicine Edition
基金
吉林省科技厅重点课题 (1 9890 31 0 - 0 5 )
吉林省中医管理局科研基金重点课题 (98A1 7)
关键词
刺五加
皂苷类
脑缺血
血流动力学
血小板粘附
血小板聚集
Acanthopanax senticosus
saponins
cerebral ischemia
hemodynamics
platelet adhesiveness
platelet aggregation
