摘要
目的 :了解本院产超广谱β-内酰胺酶 ESBL s菌株的检出率、分布及耐药特点 ,以指导临床科学合理地使用抗生素。方法 :对 4 12株革兰氏阴性杆菌采用 K- B纸片法筛选试验和双纸片法表型确证试验检测 ESBL s。结果 :4 12株革兰氏阴性杆菌中检出产 ESBL s菌 14 5株 ,检出率为 35 .2 % ,以大肠埃希菌和克雷伯氏菌为主 ;主要分布在内科 (5 2 .4% )及外科 (36 .6 % ) ,二者占了产 ESBL s菌感染总数的 89.0 % ,而感染标本以痰 (45 .5 % )、尿 (2 5 .5 % )和伤口分泌物(18.6 % )为主 ;产 ESBL s和不产 ESBL s菌对 11种抗生素的耐药率比较 ,各组均有显著差异 (P<0 .0 0 5 ) ,产 ESBL s菌株的耐药率明显高于不产 ESBL s菌株。结论 :产 ESBL s菌株的感染及耐药率严重 ,微生物实验室和临床医生必须高度重视 ESBL s的检测工作 ;亚胺培南和哌拉西林 +他唑巴坦是治疗产 ESBL s菌感染的首选药物。
Purpose To investigate the detective rate and distribution and drug tolerance of the strains can produce ultra-broad-spectrum β- lactamase to inspect clinical rational application of antibacterial drugs. Methods Detect ESBLs strain during 412 gram-negative bacteria by means of K-B paper screen and double paper validating methods. Results 145 strain ESBLs were detected with a detective rate of 35.2 %, in which the Escherichia coli and Klebsiella pneumoniae were the most and mainly distributed in internal medicin (52.4 %) and surgery (36.6 %) depart, about 89.0 % of ESBLs strains. The specimens include ESBLs strains were mostly sputum (45.5 %) urine (25.5 %) and wound secretion (18.6 %). Comparison of the drug tolerance between ESBLs and other strains show a significance difference (p<0.005), ESBLs were higher. Conclusion The infection rate and drug tolerance of ESBLs strains were severe, and the preferred drugs are recommended to be imine-peina and tapazole.
出处
《实用医技杂志》
2004年第05A期566-568,共3页
Journal of Practical Medical Techniques
关键词
超广谱Β-内酰胺酶菌
耐药性
菌株
细菌
Gram-negative bacteria
Ultra-broad-spectrum β- lactamase
Drug tolerance
