摘要
目的了解慢性腹泻飞行员肠道菌群中产超广谱β-内酰胺酶(extended spectrumβ-lactamase,ESBLs)菌的检出及耐药情况,并探讨抗菌药物对ESBLs大肠埃希菌产生的影响。方法 2010年12月—2013年10月选择某飞行学院慢性腹泻飞行员112例,留取受检者的粪标本检测产ESBLs菌,对产ESBLs大肠埃希菌(产ESBLs大肠埃希菌组)和非产ESBLs大肠埃希菌(非产ESBLs大肠埃希菌组)耐药率及抗菌药物应用情况进行对比分析。结果慢性腹泻飞行员产ESBLs菌定植率为34.82%。产ESBLs大肠埃希菌组耐药率明显高于非产ESBLs大肠埃希菌组(P<0.05),前者仅对阿米卡星和亚胺培南的敏感率>80%。抗菌药物、头孢菌素类或氟喹诺酮类药物应用、应用抗菌药物种类多(≥2种)与ESBLs大肠埃希菌产生密切相关(P<0.05,P<0.01)。结论慢性腹泻飞行员产ESBLs菌定植率较高,需要积极明确病因、排除致病菌感染、减少抗菌药物应用、对产ESBLs细菌携带者适当采取隔离措施,以控制产ESBLs菌的定植传播。
Objective To investigate the detection rate and drug resistance of extenden spectrum beta-lactamase （ ESBLs）bacterium in intestinal flora of pilots with chronic diarrhea,and to explore the influence of antibacterials on the generation of ESBLs positive escherichia coli. Methods A total of 112 pilots with chronic diarrhea in one flight college during December 2012 and October 2013 were selected. The ESBLs of faeces samples were detected. The contrastive a-nalysis of drug resistance and antibacterials use was performed between ESBLs positive escherichia coli group（ group A） and ESBLs negative escherichia coli group（ group B）. Results The colonization rate of ESBLs bacterium in chronic di-arrhea pilots was 34. 82%. The drug resistance rate in group A was significantly higher than that in group B（P〈0. 05）, and sensitivity rates to Amikacin and Imipenem in group A were more than 80%. The generation of ESBLs was closely correlated with the use of antibacterials,Cephalosporins or Fluoroquinolones,and multiple use of antibiotics（≥2 kinds） （ P〈0. 05,P〈0. 01）. Conclusion The colonization rate of ESBLs bacterium in chronic diarrhea pilots is high,so cli-nicians should actively confirm the etiology,eliminate pathogens infection,reduce antibiotic use and provide insulation methods to ESBLs bacterium carrier in order to control the transmission of ESBLs bacterium.
出处
《解放军医药杂志》
CAS
2014年第9期89-92,共4页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
