摘要
目的 观察二甲双胍对大鼠血清性激素含量的影响。方法 用放射免疫分析法 (RIA)观察二甲双胍对大鼠血清性激素含量的影响。结果 二甲双胍 (135mg·kg-1·d-1,灌胃 ,14d)可明显降低雌性大鼠血清黄体生成素 (LH)及雄性大鼠睾酮 (T)的水平 ,对雌性大鼠卵泡刺激素 (FSH)、雌二醇 (E2 )、孕酮 (P)的含量和雄性大鼠血清LH、FSH的含量均无显著影响。二甲双胍 (2 70mg·kg-1·d-1,灌胃 ,14d)可降低雄性大鼠血清T的含量 ,而对LH ,FSH无显著影响 ;可明显降低雌性大鼠血清LH的含量 ,升高其P ,E2 的含量。结论 二甲双胍可降低雌性大鼠LH及雄性大鼠T水平 ,升高雌性大鼠E2 ,P的含量 。
Objective To study the effects of Metformin(MF) on the serum sex hormone concentrations in rats.Methods The serum hormone concentrations were measured by radioimmunoassay(RIA).Results MF(135mg·kg -1·d -1,ig,14d)decreased serum T concentration in male rats and serum LH concentrations in female rats significantly(P<0.05,P<0.01),respectively,but had no effects on serum LH,FSH concentrations in male rats and serum P,E 2 concentrations in female rats.MF(270mg·kg -1·d -1,ig,14d)decreased serum T concentrations while had no effect on serum FSH,LH concentration level in male rats,but increased serum E 2 and P concentration while decreased serum LH concentrations level significantly in female rats(P<0.01).Conclusion Metformin had inhibitory effects on serum LH(♀),T(♂)concentrations but stimulative effects on serum P,E 2 concentrations in female rats.Metformin had no effects on secretory function of FSH.
出处
《潍坊医学院学报》
2004年第2期97-99,共3页
Acta Academiae Medicinae Weifang
关键词
二甲双肛
性激素
放射免疫
Metformin
Sex hormones
Radioimmunoassay
