摘要
目的探讨甲状腺全切除术后血清1 h完整甲状旁腺素(1 h-iPTH)的测定在早期预测低钙血症中的临床价值。方法 103例甲状腺全切除患者于术后1及24 h分别检测血清1 h-iPTH及24 h校正血钙(24 h-cCa)。结果 103例甲状腺全切除患者术后低钙血症的发生率为37.9%(39/103),其中低钙血症患者1 h-iPTH水平显著低于血钙正常患者(P<0.01)。术后1 h-iPTH<16 pg/mL患者低钙血症的发生率显著高于1 h-iPTH≥16 pg/mL患者(P<0.01)。以术后1 h-iPTH<16 pg/mL作为术后低钙血症的预测指标,其敏感性、特异性和准确率分别为82.1%、90.6%和87.4%。结论甲状腺全切除术后1 h-iPTH与术后低钙血症的发生存在较强的相关性,术后1 h-iPTH可以作为诊断低钙血症的指标。
Objective To investigate the early predictive significance of serum 1 h intact parathyroid hormone （ l h- iPTH） determination in patients with hypocalcemia after total thyroidectomy. Methods A total of 103 patients undergoing total thyroidectomy were enrolled, and 1 h-iPTH and serum 24 h corrected calcium （24h-eCa） levels were determined after total thyroidectomy 1 h and 24 h. Results Among the 103 patients undergoing total thyroidectomy, the incidence of postoperative hypocalcemia was 37.9% （39/103）, and the lh-iPTH level in patients with hypocalcemia was lower than that in patients with normocalcemia （P 〈 0.01 ）. The incidence of hypocalcemia in patients with 1 h-iPTH 〈 16 pg/mL was higher than that in patients with 1 h-iPTH≥16 pg/mL（P 〈0.01 ）. When lh-iPTH 〈 16 pg/mL was as a predictor for hypocalcemia, the sensitivity, specificity and accuracy were 82.1% , 90.6% and 87.4% , respectively. Conclusions lh-iPTH after total thyroidectomy shows a strong correlation with postoperative hypocalcemia, and could be as an indicator for diagnosing hypocalcemia.
出处
《检验医学》
CAS
2013年第6期475-478,共4页
Laboratory Medicine
