摘要
目的 了解带状疱疹患者细胞免疫功能与血液流变学的变化。方法 采用双抗体夹心ELISA法检测血清可溶性白细胞介素 2受体 (sIL 2R) ,流式细胞仪测定外周血T淋巴细胞亚群 (CD3 + ,CD4+ ,CD8+ )及红细胞C3b受体花环 (RBC C3 bRR)和红细胞免疫复合物花环 (RBC ICR)试验 ,同时对患者进行血液流变学检测。结果 带状疱疹组sIL 2R明显高于正常组 (P <0 .0 1) ,T淋巴细胞亚群CD3 + ,CD4+ ,CD8+ 与正常组比较明显降低 (P <0 .0 1) ,CD4+ /CD8+ 与正常组比较均降低 (P均 <0 .0 5 ) ;RBC C3bRR较正常组明显降低 (P <0 .0 1) ,RBC ICR与正常组比较明显增高 (P <0 .0 1) ,血液流变学检测示患者血黏度增高。结论 带状疱疹患者存在细胞免疫功能亢进及紊乱及血黏度增高学。
Objective To study effect of rehabilitation in herpers zoster with cell immune function and hemorheological changes.Methods The levels of soluble interleukin-2 receptors (SIL-2R) were measured by ELISA T-lymplocyte subsets (CD_3 +,CD_4 +and CD_8 +) were also evaluated by flow cytometry (FCM).The red blood cell C_ 3b receptor rosette (RBC-C_ 3b RR),red blood cell immune complexs resstte (RBC-ICR) were measured,patient’s hemorheological changes were tested.Results Serum sIL-2R levels were significantly higher in Herpers zoster than normal subjects( P <0.01) CD_3 +,CD_4 +,CD_8 +were significantly lower in Herpers Zoster than normal subjects( P <0.01),CD_4 +/CD_8 + ratio were lower than in normal subjects ( P <0.05).RBC-C_ 3b RR were significantly increased( P <0.01) RBC-ICR were significantly increased( P <0.01).Hemoheological changes in plasma viscosity was increased.Conclusion Patient in Herpers zoster may be treated by immune regulation.To regulate cell immune function and decrese plasma viscosity attain rehabilitation.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2004年第5期267-268,共2页
The Chinese Journal of Dermatovenereology
