摘要
目的 比较不同方法治疗原发性肝癌细胞凋亡和c myc蛋白表达的关系。 方法 采用原位末端标记法 (ISEL)和SAB免疫组化法对 12 0例原发性肝癌分组测定细胞凋亡和c myc蛋白的不同的表达。 结果 治疗组细胞凋亡阳性率和c myc蛋白表达的阳性率均高于对照组 (P <0 0 5～ 0 0 1) ,肝癌细胞凋亡指数(0 2 90 1)明显高于对照组凋亡指数 (0 0 188,P <0 0 1) ;直径≥ 10cm中晚期肝癌生存率低于直径 <10cm中晚期肝癌 (P <0 0 5～ 0 0 1) ;细胞凋亡与c myc蛋白表达呈正相关 (γ =0 5 6 4 5 ,P <0 0 5 )。治疗组的疗效均高于对照组 (P <0 0 1) ;联合治疗高于单项治疗 (P <0 0 5 )。结论 c myc蛋白表达水平升高与肝癌细胞凋亡有关 。
Objective In order to investigate the effect of c mycon hepatic apoptosis in hepatocellular carcinoma(HCC) after transcatherarterialchemoembolization(TACE).Methods Expression of c myc in HCC tissues was detected by immunohistochemical method and apoptosis by ISEL method in the 120 patients with HCC who had been treated by TACE(TACE group) and 30 patients without any treatments(no TACE group).Results Expression rate of c myc in HCC tissues of TACE group and no TACE group was 16.67% and 83.33% respectively.Apoptosis indexes in HCC tissues of TACE group and no TACE group were 0.0088 and 0.1901 respectively.The results indicated that after arterial chemo embolization,the apoptosis rate in HCC was raised,the expression rate of c myc in HCC tissues was significantly increased.Conclusion c myc might play an important role in enhancing hepatic apoptosis in HCC.
出处
《中国基层医药》
CAS
2004年第3期303-304,共2页
Chinese Journal of Primary Medicine and Pharmacy
