摘要
目的 :比较苯那普利与苯磺酸左旋氨氯地平和硝本地平缓释片合用 ,治疗单用苯那普利不能控制其血压降至目标水平的原发性高血压患者的疗效、副反应。方法 :112例单用苯那普利治疗不能控制至理想血压的患者 ,在原有剂量不变下 ,加用苯磺酸左旋氨氯地平或硝本地平缓释片治疗 ,用药后 4周判断降压效果 ,不良反应。结果 :加用苯磺酸左旋氨氯地平后有效率为 85 .71% ,加用硝本地平缓释片为 78.5 7% ,两组无显著的统计学意义 (P >0 .0 5 ) ,加用苯磺酸左旋胺氯地平后的显效率有(73.2 1% )高于加用硝本地平缓释片 (5 4.38% ,P <0 .0 5 ) ;不良反应显著低于加用硝本地平组 (7.14 %vs 2 8.5 % ,P <0 .0 1)。结论 :对单用苯那普利治疗不能控制其理想血压的患者 ,苯那普利合用苯磺酸左旋胺氯地平或苯那普利合用硝本地平缓释片治疗都是有效的。苯那普利和苯磺酸左旋胺氯地平联合更适合于此类病人的抗高血压治疗。
AIM : To compare the therapy of the combination of benazepril and levamlodipine (B/LA) with benazepriland and nifedepine sustained-release tablet (B/NSr) in patients with mild to moderate hypertension inadequately controlled by benazepril alone. METHODS : Experiments were performed in 112 patients with primary hypertension inadequately controlled by benazepril alone. The patients were randomized divided into two groups. Continued previous benazepril treatment, the B/LA group( n =56) was added levamlodipine, 2.5 mg once daily for 2 weeks, the B/NSr group ( n =56) was added nifedepine sustained-release tablets,10 mg once daily for 2 weeks. Examinations were performed before and at the end of 2 weeks of combination-treatment period. The total combination-treatment period was 4-6 weeks. RESULTS : The overall Bp-reducing efficacious rate of LA/B group was 85.71%, and that of LA/B group was 78.57% ( P > 0.05), but the obvious Bp-reducing rate in B/LA group was 73.21%, which was significantly higher than that in B/NSr group ( 57.14%, P < 0.05). The adverse effects rate was 8.93% in B/LA group and 21.43% in B/NSr group ( P < 0.01). CONCLUSION : Either LA/B or B/NSr is effective in the treatment of hypertension inadequately controlled by benazepril alone, but LA/B is more desirable therapy than B/NSr.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2004年第4期470-473,共4页
Chinese Journal of Clinical Pharmacology and Therapeutics
