期刊文献+

髓性过氧化物酶与动脉粥样硬化相关性研究进展 被引量:3

Relationship between myeloperoxidase and atherosclerosis
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摘要 髓性过氧化物酶是由活化的吞噬细胞分泌的相对分子质量为 75× 2kDa的一种血红素蛋白。它能通过作用于氯化物和酪氨酸 ,分别生成次氯酸和酪氨酰基 ,启动低密度脂蛋白的过氧化 ,产生氧化型低密度脂蛋白 。 Myeloperoxidase is a kind of hemoprotein(molecular weight 75×2?kDa) secreted from activated phagocyte.It can act on chloride and tyrosine to form hypochlorous acid and tyrosyl which can initiate the pro oxidation of lowdensity lipoprotein and promote the development of atherosclerosis ultimately.
出处 《现代医学》 2004年第2期136-138,共3页 Modern Medical Journal
关键词 髓性过氧化物酶 动脉粥样硬化 相关性研究 氧化型低密度脂蛋白 myeloperoxidase oxidized low density lipoprotein atherosclerosis
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参考文献18

  • 1ANDREWS P C.The reductive cleavage of myeloperoxidase in half,producing enzymaticallyactive hemimycloperoxidase[J].Biol Chem,1981,256(9):4211. 被引量:1
  • 2UEDA T,SAKAMAKI K,NAGATA S,et al.Molecular cloning and characterization of the chromosomal gene for human lactoperoxidase[J].Eur J Biochem,1997,243(7):32-41. 被引量:1
  • 3ISHIDA-OKAWARA A,OHARASI T,TAKAHASHI K,et al.Contribution of myeloperoxidase to coronary artery vasculitis associated with MPO- ANCA production[J].Inflammation,2001,25(6):381-387. 被引量:1
  • 4PODREZ E A,FEBBRAIO M,SHEIBANI N,et al.Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species [J].Clin Invest,2001,105(13):1095-1108. 被引量:1
  • 5MARCINKIEWICZ J.Prostanoids and MPO-halid system products as a link between innate and adaptive immuuity[J].Immunol Lett,2003,89(2-3):187-191. 被引量:1
  • 6HAZELL L J,BAERNTHALER G,STOCKER R,et al.Correlation between intima-to-media ratio,apolipoprotein B- 100,myelope-roxidase,and hypochlorite-oxidized proteins in human atherosclerosis [J].Free Radic Biol Med,2001,31(10):1254-1262. 被引量:1
  • 7HEINECKE J W,DAEHNKE H L.Oxidants and antioxidants in the pathogenesis of atherosclerosis:implication for the oxidized low density lipoprotein hypothesis[J] Atherosclerosis,1998,14(1):1-15. 被引量:1
  • 8ARATAN I Y,KURA F,WATANABE H,et al.Relative contributions of myeloperoxidase and NAPDH-oxidase to the early host defence against pulmonary infections with Candida albicans and Aspergillus fumigatus[J].Med Mycol,2002,40 (6):557-563. 被引量:1
  • 9YUE K T,TAYLOR K L,POWERS L S,et al.X-ray absorption and resonance raman spectroscopy of human myeloperoxidase at neutral and acid pH[J].Biochem Biopsy Acta,1997,13(38):282-294. 被引量:1
  • 10KETTLE A J,WINTERBOURN C C.Myeloperoxidase:a key regulator of neutrophil oxidant[J].Redox Report,1997,3(26):3-15. 被引量:1

同被引文献54

  • 1贾克刚,刘军锋,马明坤,韩雪晶,柴俊岩.血清髓过氧化物酶和高敏C反应蛋白与冠状动脉粥样硬化的相关性研究[J].检验医学,2007,22(2):179-181. 被引量:5
  • 2苏淑红,刘志强,严松彪,陈晖.髓过氧化物酶与急性冠脉综合征[J].北京医学,2007,29(4):235-237. 被引量:6
  • 3Batt KV, Avella M, Moore EH, et al. Differential effects of low-density lipoprotein and chylomicron remnants on lipid accumulation in human macrophages[J]. Exp Biol Med, 2004, 229(6):528-537. 被引量:1
  • 4Kennedy S, Fournet-Bourguignon MP, Breugnot C, et al. Cells derived from regenerated endothelium of the porcine coronary artery contain more oxidized forms of apolipoprotein-B-100 without a modification in the uptake of oxidized LDL[J]. J Vasc Res, 2003, 被引量:1
  • 5Fu T, Borensztajn J. Macrophage uptake of low-density lipoprotein bound to aggregated C-reactive protein: possible mechanism of foam-cell formation in atherosclerotic lesions [J]. Biochem J,2002, 366: 195-201. 被引量:1
  • 6Virella G, Atciley D, Koskinen S, et al. Proatherogenic and proinflammatory properties of immune complexes prepared with purifed human oxLDL antibodies and human oxLDL[J]. Clinical Immunology, 2002, 105(1): 81-92. 被引量:1
  • 7Monaeo C, Paleolog E. Nuelearfactor kappaB: a potential therapeutic target in artheroscleresis and thrombosis[J]. Cardiovase Res, 2004,61:671-682. 被引量:1
  • 8王媛媛,黎莉,周风华,孟晓,钟明,张薇,张运.急性冠状动脉综合征患者外周循环中性粒细胞髓过氧化物酶测定的临床意义[J].山东大学学报(医学版),2007,45(10):996-999. 被引量:3
  • 9TIBOLLA G,NORATA G D,ARTALI R,et al.Proprotein convertase subtilisin/kexin type 9 (PCSK9): from structure-function relation to therapeutic inhibition. Nutrition, metabolism, and cardiovascular diseases[J].NMCD,2011,21:835-843. 被引量:1
  • 10STEINBERG D,WITZTUM J L.Inhibition of PCSK9:a powerful weapon for achieving ideal LDL cholesterol levels[J].P Natl Acad Sci USA,2009,106:9546-9547. 被引量:1

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