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PCSK9在脂代谢调节中作用的研究进展 被引量：6

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摘要 血清中低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)浓度与冠心病的发生密切相关,而LDL-C主要是通过肝细胞表面的LDL受体(LDL receptor,LDLR)清除。前蛋白转化酶枯草溶菌素9(proprotein convertase subtilisin kexin type 9,PCSK9)可结合肝细胞表面LDLR并与其共同内吞入内体,介导LDLR进入溶酶体使其降解,从而参与血胆固醇的调节,在维持脂代谢稳态中发挥重要作用。目前对PCSK9的研究已取得一定的进展,但其发挥作用的确切机制还不是很清楚,在本文中作者就PCSK9在脂代谢调节中的作用以及其发挥作用的分子机制作一综述。
作者 张洋 马坤岭
机构地区 东南大学附属中大医院肾内科
出处 《东南大学学报（医学版）》 CAS 2013年第4期473-478,共6页 Journal of Southeast University(Medical Science Edition)
基金 国家自然科学基金资助项目(8107057)
关键词 前蛋白转化酶枯草溶菌素9 低密度脂蛋白受体 脂代谢 文献综述
分类号 R333.6 [医药卫生—人体生理学]
  • 相关文献

参考文献42

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二级参考文献19

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共引文献5

同被引文献42

  • 1杨全坤.血脂康胶囊治疗对冠心病伴血脂异常患者临床观察[J].中外医学研究,2013,11(20):177-177. 被引量：5
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引证文献6

二级引证文献15

东南大学学报（医学版）
2013年 第4期

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