摘要
作者对服用抗癫痫药物的46例癫痫患者、20例未服用抗癫痫药物的癫痫患者和50例健康人进行了外周血淋巴细胞微核率检测。结果显示:服用抗癫痫药物的癫痫患者淋巴细胞微核率较健康人组高(P<0.001),亦较未服药癫痫组高(P<0.01～0.001)。
We studied the micronuclear rates of peripheral blood lymphocytes in 46 epi- leptic patients who were on antoepileptic drugs, 20 epileptic patients who had not taken any antiepileptic 6 months before the study, and 50 healthy persons as normal controls.The results showed that there were statistically increased micronuclear rates for the epileptic patient groups (P<0.01～0.001). The patient groups hadfrequencies of 6.100‰±3.093‰, 5.333‰±3.792‰ and 5.000‰±3.256‰, but the healthy controls had only 1.862‰±1.187‰ and the epileptic controls 3.000‰±1.076‰.Thus we conclude that antiepliptic drugs are detrimental to the genetic material of epileptic patients.
出处
《中华医学遗传学杂志》
CAS
CSCD
北大核心
1992年第1期13-14,共2页
Chinese Journal of Medical Genetics
关键词
微核率
癫痫
抗惊厥药
Micronuclear rates Epilepsy Anticonvulsants
