摘要
检测15 例单服卡马西平(CBZ) 及15 例服用CBZ 加叶酸(FA) 的癫痫患者外周血淋巴细胞姊妹染色单体交换(SCE) 频率,同时用放射免疫法测定其血清叶酸值,并与未服药癫痫对照组及正常对照组进行比较。结果显示,单服CBZ 组的SCE 频率较服用CBZ加FA 组及对照组高,其血清FA 值下降。提示CBZ可引起癫痫患者SCE 频率升高、血清叶酸值减少,补充叶酸可有效防止CBZ 引起的染色体DNA
Peripheral blood lymphocyte sister chromatid exchange(SCE) frequencies, serum folic acid(FA) levels were examined in 15 epileptic patients treated with carbamazepine(CBZ), and another 15 epileptic patients treated with CBZ and folic acid(FA). The untreated epileptic patients and the healthy subjects served as control. The results showed that SCE frequencies were significantly higher in CBZ Group, compared with CBZ plus FA Group and control(P<0.01). Serum FA levels were lower in CBZ Group compared with healthy control(P<0.01). It suggests that CBZ can induce the increase of SCE frequencies. Supplementation with FA may effectively prevent chromosome DNA damage induced by CBZ.
出处
《湖南医科大学学报》
CSCD
1999年第6期563-565,共3页
Bulletin of Hunan Medical University
关键词
卡马西平
癫痫
叶酸
SCE频率
carbamazepine
epilepsy
sister chromatid exchange
folic acid
therapeutic use
