摘要
目的 :探讨碱性成纤维细胞生长因子 (b FGF)在前列腺增生和前列腺癌组织中表达的临床意义。方法 :采用斑点杂交技术和免疫组化染色 ,测定 40例正常前列腺 (NP)、3 8例前列腺增生症 (BPH )和 3 6例前列腺癌组织 (Pca)中b FGF的表达。结果 :BPH和Pca组织中 ,b FGF的表达明显高于NP组织 (P <0 .0 1)。b FGF表达升高的程度与BPH的分度、Pca的病理分级和临床分期均无明显关系。结论 :b FGF可能为BPH和Pca组织自身分泌 。
AIM: To investigate the clinical significance of basic fibroblast growt h factor (b-FGF) in human benign prostatic hyperplasia (BPH)and prostati c carcinoma(Pca). METHODS: b-FGF expressions were examine d by RNA dot blot hybridization and immunohistochemical staining in prostate ti ssues from 40 normal cases (NP), 38 BPH and 36 Pca. RESULTS: Th e expressions of b-FGF in BPH and Pca tissues were significantly higher than thos e in normal prostate tissues(P<0.01).There was no significant correlation between the increased expression of b-FGF and the graduation of BPH, pathologi c grading as well as clinical stages of Pca. CONCLUSION: b-FGF may be secreted from BPH and Pca t issues themselves, which is closely involved in the genesis and development of B PH and Pca.
出处
《细胞与分子免疫学杂志》
CAS
CSCD
北大核心
2004年第2期203-205,共3页
Chinese Journal of Cellular and Molecular Immunology
关键词
前列腺增生
前列腺癌
碱性成纤维细胞生长因子
benign prostatic hyperplasia
prostatic carcin oma
basic fibroblast growth factor
