摘要
目的观察血啉甲醚介导光动力辅助显微手术治疗脑胶质瘤的近期疗效和随访效果。方法1999年至2001年期间,34例恶性脑胶质瘤病人给予光动力辅助手术治疗。暴露肿瘤前3h,静脉推注光敏剂,显微镜下切除肿瘤后应用光动力治疗仪对肿瘤残腔进行激光照射(200J/cm2)以杀伤残存肿瘤细胞。术后避光3d,观察近期临床表现,出院后定期随访治疗效果。结果术后近期效果满意临床症状缓解或消失,出院时Karnofsky记分升高者28例,Karnofsky记分无变化者6例,Karnofsky记分改善率82%(28/34);全部病例无皮肤光敏反应;术后1年生存率为77%(26/34);术后2年生存率为53%。结论激光光动力疗法是一种有效的脑胶质瘤辅助治疗方法近期临床效果满意,有利于提高生存率和生存质量,延长患者生命。
Objective To report the technique and follow-up effect of treating 34 patients with malignant glioma by combination of photodynamic therapy using hematoporphyrin monomethyl Ether and Operation. Methods 34 patients with malignant gliomas was given the photodynamic therapy during the operation. the photosensitizer was infused into the vein of the patient(5mg/kg) at 3h before exposing the tumor.The laser irradiated the tumor's cavity for killing these survival tumor's cells after resecting the tumor under the microscopy(200J/cm2). 34 patients who underwent tumor resection combined with PDT were followed-up. Results In this group the skin phototoxic reaction can not to be observed the rate of a melioration of postoperative KPS score was 82%,the 1-year survival rate of these 34 patients was 77%, 2-year survival rate was 53%. Conclusion All the results indicate that photodynamic therapy is an effective assistant approach for treating gliomas It is necessary for improve surgical outcome and patient's life quality?
出处
《中华神经外科杂志》
CSCD
北大核心
2004年第1期30-32,共3页
Chinese Journal of Neurosurgery
基金
国家自然科学基金(项目号:30200086)
关键词
显微手术
治疗
脑胶质瘤
光动力疗法
Photodynamic therapy
Hematoporphyrin monomethyl ether
Cerebral gliomas
Microsurgical operation
