摘要
目的 检测后尿道腺瘤中雄激素受体 (AR)及表皮生长因子受体 (EGFR)的表达。方法 采用免疫组织化学S P法检测 4 0例后尿道腺瘤和 18例正常后尿道黏膜中AR和EGFR的表达。结果 后尿道腺瘤组织的AR和EGFR阳性表达显著高于正常后尿道黏膜组织。后尿道腺瘤组织中AR和EGFR的表达呈显著正相关。结论 后尿道腺瘤可能是一种雄激素依赖性肿瘤 。
Objective To study the expression of androgen receptor(AR) and epidermal growth factor receptor(EGFR) in human adenoma ofposterior urethra. Methods Immunohistochemical method was used to investigate the expression of AR and EGFR in 40 cases of posterior urethral adenoma and18 cases of normal posterior urethral mucosa. Results The expression of AR and EGFR were significantly higher in posterior urethral adenoma than in normal posterior urethral mucosa. A positive correlation was found between the expression of AR and EGFR in the posterior urethral adenoma. Conclusion Adenomaof the posterior urethra may be an androgen-dependent benign neoplasm and its pathogenesis and development may be closely associated with androgen and AR and EGFR overexpression.
出处
《山西医科大学学报》
CAS
2004年第2期112-114,共3页
Journal of Shanxi Medical University
基金
山西省自然科学基金资助项目 ( 2 0 0 110 68)
