摘要
为了给家蚕细菌病的预防和治疗提供合理用药的理论依据 ,采用微生物测定法研究了盐酸诺氟沙星在健康家蚕体内的药物动力学特征 ,以MCPKP药代动力学程序处理药时数据。结果表明 :盐酸诺氟沙星在蚕体内的药时数据符合一级吸收一室开放式模型 ,主要药物动力学参数 :T1/2Ka=1 797± 0 0 2 3h ,T1/2Kel=1 778± 0 0 12h ,Tmax=3 4 2 8± 0 0 0 8h ,Cmax=14 80 8± 0 6 4 5 μg/mL。
In order to provide advisable theoretical base for preventing and curing silkworm bacterial diseases, the pharmacokinetics of Norfloxacin·HCl in silkworms were studied by using the microbiologic assay. Data were analyzed with the pharmacokinetic computer program MCPKP. The results showed that the plasma concentration-time course of Norfloxacin·HCl can be best described by a one-compartment open model with the first order absorption. The main pharmacokinetic parameters were those: T 1/2Ka =1.797±0.023 h,T 1/2Kel =1.778±0.012 h,T max =3.428±0.008 h,C max =14.808±0.645 μg/mL。
出处
《蚕业科学》
CAS
CSCD
2004年第1期55-58,共4页
ACTA SERICOLOGICA SINICA
基金
国家茧丝绸风险基金 ( 2 0 0 2年资助项目 )
