摘要
目的 :研究复方益母草膏 (益母草、川芎、当归、红花 )治疗痛经的药理学作用机制。方法 :观察复方益母草膏对肾上腺素所致小鼠耳廓微循环障碍的影响 ,观察复方益母草膏对催产素所引起的离体大鼠子宫平滑肌收缩作用及小鼠扭体次数的影响。结果 :复方益母草膏可以明显扩张小鼠耳廓微动脉和微静脉的管径 ,加快血流的速度 ;对催产素引起的子宫平滑肌的收缩具有抑制作用 ;整体实验也证明对小鼠有减少扭体的次数 ,治疗痛经的作用。结论 :复方益母草膏具有明显的改善微循环 ,抑制催产素引起的子宫平滑肌收缩的作用 ,有助于缓解痛经。
AIM: To investigate the antidysmsenorrhea pharmacologic effects of Compound Yimucao Paste (Herba Leonuri, Rhizoma chuanxiong, Radix Angelicae Sinensis, Flos Carthami) METHODS: The methods of microcirculation and isolated uterus smooth muscle of rat were used. RESULTS: Compound Yimucao Paste could improve the microcirculation disturbance on the aspects of the diameter, the velocity of mice auricle microarterioles and microveins, inhibit the isolated uterus smooth muscle contraction and mouse twister induced by oxytocin. CONCLUSION:Compound Yimucao Paste has an obvious action of blood quickening and stasis transforming and inhibit the isolate and uterus smooth muscle contraction induced by oxytocin, which are contributed to its antidysmenorrhea effect.
出处
《中成药》
CAS
CSCD
北大核心
2004年第4期311-314,共4页
Chinese Traditional Patent Medicine
关键词
复方益母草膏
微循环
子宫收缩
痛经
Compound Yimucao Paste
microcirculation
uterus contraction
dysmenorrhea
