摘要
细胞凋亡是近年来研究的一个热点问题,涉及到细胞内许多复杂的生化过程.线粒体是真核生物能量和代谢的中心,也是细胞凋亡信号传导途径中起关键调节作用的细胞器,对细胞凋亡的线粒体途径调控机制进行研究具有重要意义.本文综述了细胞凋亡过程中线粒体途径的信号传导及其调控机制、线粒体对细胞凋亡信号的反应、细胞凋亡过程中线粒体功能丧失几方面的研究进展.
Apoptosis is the capacity of a cell to undergo programmed cell death, which involves many cellular biochemical e-vents. Mitochondria are the bioenergetic and metabolic center of eukaryotic cell. During apoptosis, many key events are related to mitochondria. The central roles for mitochondria as the orchestrators of apoptosis have been firmly established in recent years. This review summarizes the recent data on execution and regulation of mitochondrial apoptotic signals; mitochondrial response to apoptotic signals and loss of mitochondria functions during apoptosis. Fig 1, Ref 43
出处
《应用与环境生物学报》
CAS
CSCD
2004年第2期251-255,共5页
Chinese Journal of Applied and Environmental Biology
关键词
细胞凋亡
线粒体
调控
细胞程序化死亡
细胞器
信号传导
蛋白
programmed cell death
apoptosis
mitochondria
excution of signal
caspase
Bcl-2 family of proteins
BH3-only family of proteins
mitochondrial proteins
