摘要
目的:观察芍药甙对犬实验性急性重症胰腺炎(ASP)时Oddi括约肌(SO)功能的影响。方法:10只犬随机分为ASP非治疗组和芍药甙治疗组,以5％牛磺酸钠加自身胆汁制备ASP模型,于造模前,造模后30、60、90、120、180、240 min及给药后5、10、30、60、120、180 min分别测定SO的基础压(BP)和时相收缩幅度(PCA)变化。结果:ASP组与造模前比较.BP显著升高(P<0.01);芍药甙给药后能显著降低ASP时BP(P<0.05),对ASP时PCA无显著作用(P>0.05)。结论:SO压力异常是ASP发展及影响其严重程度的重要因素,芍药甙通过对SO的抑制对ASP具有潜在的治疗作用。
<abstract>jective:To study the effect of paeoniflorin on Oddi's sphincter (OS) in experimental acute severe pancreatitis (ASP). Methods: Ten dogs were randomly allocated into 2 groups equally: ASP untreated group and paeoniflorin group. The ASP model was prepared by retrograde ducta 1 injection of a mixture of 5% taurocholic acid and autologous bile. OS manometric parameters including basal pressure(BP)and phasic contraction amplitude (PCA) were measured at each time spot before and 30, 60, 90, 120, 180, 240 minutes after the preparation of ASP and 5, 10, 30, 60, 120, 180 minutes after the administration of paeoniflorin. Results: The basal pressure of OS significantly increased after the preparation of ASP( P <0. 01). In paeoniflorin group the BP of OS was significantly decreased in ASP by administration of the drug( P <0. 05) but the drug had no significant effect to PCA( P > 05 ). Conclusion :The abnormality of pressure of OS is important factor in the development and severity degree of ASP. Paeoniflorin may have potential effects on ASP by decreasing BP of OS.
出处
《中国中西医结合消化杂志》
CAS
2004年第2期77-79,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
