摘要
目的探讨生长抑素及大黄素对犬急性坏死性胰腺炎Ｏｄｄｉ括约肌压力的影响。方法杂种犬１５条，予胰管内逆行注入５％牛磺酸钠加自身胆汁诱发急性坏死性胰腺炎（ＡＮＰ）模型；随机分为ＡＮＰ非治疗组、生长抑素组和大黄素组；采用低顺应性毛细灌注测压导管及高分辨多通道胃肠动力仪于造模前及给药后测定Ｏｄｄｉ括约肌（ＳＯ）的基础压（ＢＰ）及时相收缩幅度（ＰＣＡ）。结果ＡＮＰ组与造模前正常比较，ＢＰ显著升高；生长抑素能显著降低ＡＮＰ时ＳＯ的ＢＰ及ＰＣＡ，而大黄素则无影响。结论ＳＯ功能异常是ＡＮＰ发展及影响其严重程度的重要因素，生长抑素对ＳＯ具有松弛作用，大黄素虽对ＡＮＰ有治疗作用，但对ＳＯ无松弛作用。
Objective To study the effects of somatostatin and
emodin on sphincter of Oddi (SO) in acute necrotizing pancreatitis (ANP). Methods Fifteen dogs
were used and the ANP models were induced by retrograde ductal injection of mixture of 5%
taurocholic acid and autologous bile.The dogs were then allocated into 3 groups:ANP untreated
group,somatostatin group and emodin group.SO manometry including basal pressure (BP) and
phasic contractive amplitude (PAC) were investigated before and 5,10,30,60,120,180 minutes
after ANP and the administration of above drugs. Results The BP was obviously increased after
ANP and Somatostatin can significantly decrease the BP or PCA on SO in ANP,however,Emodin
had no any effect on SO. Conclusion The dysmotility of SO plays an important role in the
progression of ANP and it may also affect the severity of this disease;somatostatin has
beneficial effects on SO in ANP.Although Emodin has effects on ANP,there was no effect on SO
in ANP.
出处
《中华消化杂志》
CAS
CSCD
北大核心
1999年第4期252-255,共4页
Chinese Journal of Digestion
基金
国家自然科学基金
关键词
生长抑素
大黄素
急性
胰腺炎
ODDI括约肌
测压
SomatostatinEmodinAcute necrotizing pancreatitisSphincter of
OddiManometry
