摘要
目的 研究环氧化酶 2 (COX 2 )在乳腺浸润癌中的表达情况及其与乳腺癌临床病理特征的关系。方法 应用免疫组织化学 (SP法 )检测 83例乳腺浸润癌 (其中有周围组织浸润 6 2例 ,伴腋淋巴结转移 4 7例 )和 35例癌旁组织中COX 2的表达。结果 COX 2在乳腺浸润癌中的阳性表达率为 73.5 %(6 1/ 83) ,显著高于癌旁组织 (P <0 .0 0 1) ;乳腺浸润癌组织COX 2的表达与临床分期、周围组织浸润和淋巴结转移密切相关 ,(P <0 .0 5 ,P <0 .0 5 ,P <0 .0 0 1) ,与患者年龄和肿瘤大小无明显相关性。结论 COX 2蛋白表达可能在乳腺浸润癌的发生、发展中起重要作用。
Objective To study the expression of cyclooxygenase -2(COX-2) in breast invasive carcinoma and its clinicopathologic significance.Methods The expression of COX-2 was detected with SP immunohistochemical analysis in 83 cases of breast invasive carcinoma (including 62 cases with surrounding invasion,47 cases with lymph node metastasis) and 35 non-cancerous specimens.Results The positive rate of COX-2 in breast invasive carcinoma was 73.5% (61/83),which was significantly higher than those in non-cancerous specimens (P< 0.001 ). The expression of COX-2 was correlated with clinical stage,invasion and lymph node metastases (P< 0.05 ,P< 0.05 ,P< 0.001 ),but there was no correlation with age and tumor size.Conclusion COX-2 protein expression may be playing an important role in the development of breast invasive carcinoma.
出处
《肿瘤防治研究》
CAS
CSCD
2004年第4期206-207,共2页
Cancer Research on Prevention and Treatment
