摘要
目的 了解青年人大肠癌的预后是否受家族遗传背景的影响。方法 将年龄小于 40岁、经手术治疗、有病理资料、详细的家系调查、并有随访结果的患者分成有家族遗传背景和无家族遗传背景两组进行分析比较。结果 44例患者符合上述标准 ,有家族遗传背景组 (A组 ) 12例 ,无家族遗传背景组 (B组 ) 3 2例 ,5年生存率分别为 83 .3 0 % ( 10 /12 )和 5 9.3 8% ( 19/3 2 ) ,两组具有显著性差异 ( χ2 =5 .64 ,P <0 .0 5 )。A组分化较好和分化较差的癌分别为 8例和 4例 ;B组分别为 19例和 13例。按病理类型计算两组标准化 5年生存率 ,分别为 84.0 9% ( 3 7/4 4)和 5 9.0 9% ( 2 6/4 4) ( χ2 =6.68,P <0 .0 5 )。Dukes分期 :A组B期 9例 ,C期 3例 ;B组B期 14例 ,C期 18例。按Dukes分期计算两组标准化 5年生存率 ,分别为 88.64 % ( 3 9/4 4)和 63 .64 % ( 2 8/4 4) ( χ2 =6.5 8,P <0 .0 5 )。结论 青年人大肠癌的预后可能受家族遗传背景的影响。有必要综合国内遗传性非息肉病性大肠癌家系中的青年人病例 ,与散发性大肠癌家系中的青年人大肠癌进行进一步研究与比较 ,以对青年人大肠癌的预后作出正确的评价。
Objective To investigate if the prognosis of young patients with colorectal cancer (CRC) is influenced by their familial predisposition. Methods The patients with CRC under 40 years old, underwent operation, had pathological diagnosis , family survey, followed up etc were selected into this research. According to familial predisposition they were divided into two groups: group A (with familial predisposition) and group B (without familial predisposition). Results Among the 44 patients twelve were in group A, thirty-two in group B. The 5-year survival rate in group A and B was 83.30%(10/12) and 59.38%(19/32) respectively,the difference was significant between the two groups(χ 2=5.64,P<0.05). The cases of well differentiated cancer and poorly differentiated cancer in group A and B were 8, 4 and 19,13 respectively. Adjusted for histopothology difference, the standard 5-year survival rate in group A and B was 84.09%(37/44)and 59.09%(26/44)respectively(χ 2=6.68,P< 0.05). Patients in Dukes stage A ,B and C were 3, 14 and 18. Adjusted for Dukes classification difference,the 5-year survival rate in group A and B was 88.64%(39/44) and 63.64%(28/44) respectively (χ 2=6.58,P< 0.05). Conclusions The prognosis of young patients with CRC may be influenced by their familial predisposition. It is necessary to collect more cases of young patients in HNPCC families for further study and to compare them with sporadic cases to evaluate the prognosis of goung patients with CRC correctly.
出处
《中国普通外科杂志》
CAS
CSCD
2004年第4期249-252,共4页
China Journal of General Surgery
