摘要
目的:分析青年人大肠癌的临床特点及遗传背景。方法:收集昆明医学院第一附属医院1989年～2007年间收治的229例年龄≤40岁青年性大肠癌患者的资料,与同期收治的年龄60岁以上的818例老年大肠癌患者作为对照,进行回顾性分析。结果:青年人大肠癌占同期大肠癌的13.65%;临床症状以大便性状改变和血便为主,但与老人组相比,发生率差异无统计学意义(P<0.05);发病部位直肠为主;组织学类型以黏液腺癌和印戒细胞癌、低分化腺癌、未分化癌为主占66.4%;TNM分期以Ⅲ期和Ⅳ期为主,占71.7%;遗传背景分析发现,有家族史的青年性大肠癌患者占14.0%,与老年组相比,差异均有统计学意义(P<0.05)。结论:青年性大肠癌发病隐匿,临床症状不明显,早期诊断困难。组织类型分化较差;遗传在青年性大肠癌发病上起重要作用。
Objective： To study the clinical characteristics and hereditary susceptibility of young patients with colorectal cancer. Methods： Two hundred and twenty-nine young patients（≤40 years old）with colorectal cancer pathologically confirmed form 1989 to 2007 in the First Affiliated Hospital of Kunming Medical College were involved in this study. Eight hundred and eighteen cases of colorectal cancer patients over 60 years old hospitalized simultaneously were used as control. The clinicopathological data of all patients were reviewed retrospectively. Results： Young patients with colorectal cancer accounted for 13.65% of all colorectal cancer during the same period. Bloody and mucinous stool were the main clinical symptoms. Most of the cancer originated from the rectum and signet ring cell carcinoma, mutinous adenocareinoma, poor differentiated adenocaroinoma and undifferentiated carcinoma were the main histological types 66.4%. The majority of patients （71.7 % ） were in TNM stage m and stage IV. Young patients who had hereditary background of eoloreetal cancer accounted for 14.0% of young eolorectal cancer group. Conclusion ： ColoreetaI cancer of young patients is invasive with poor prognosis and the onset is atypical. It is hard to diagnose this disease in the early stage correctly. Inheritance may play an important role in tumorigenesis of colorectal cancer in young patients.
出处
《肿瘤预防与治疗》
2012年第1期21-23,共3页
Journal of Cancer Control And Treatment
基金
云南省社会发展科技计划项目资助(2007CA009)
关键词
青年人
大肠癌
临床特点
遗传易感性
Young Patients
Colorectal Cancer
Clinical Characteristics
Hereditary Susceptibility
