摘要
采用溶液浇铸 -颗粒滤除法制备了聚 DL-乳酸 (PDL L A) ,聚 DL-乳酸 /羟基磷灰石 (PDL L A/ 2 0 wt%HA)、及聚 DL-乳酸 / β-磷酸三钙 (PDL L A/ 2 0 wt% β- TCP)复合多孔支架材料。研究了支架材料在体外降解中压缩强度、分子量、质量及水解液的 p H值变化规律。结果显示 :复合多孔支架中 HA和 β- TCP均匀分布在 PDL L A基质中 ,复合支架的孔隙率可达 84 % ,磷酸盐微粒的加入对多孔支架的孔隙率有一定的影响 ,但可提高多孔支架的压缩强度 ,并可中和 PDL L A降解所产生的酸性 ,延缓 PDL L A的降解速度。两者相比 。
The porous foams were prepared by the solvent casting and particulate leaching technique using poly(DL lactide)(PDLLA), poly(DL lactide)/hydroxyapatite(PDLLA/20wt%HA), and poly(DL lactide)/β tricalcium phosphate(PDLLA/20wt%β TCP) respectively. Observations by scanning electron microscopy indicated that the HA and β TCP were homogeneously dispersed in the polymer matrix, and the pores of the foams are interconnected, resulting in continuous pore structures. The porosity of PDLLA/HA and PDLLA/β TCP foams was lower than that of the pure PDLLA foams, but the compression strength was higher than that of the pure PDLLA foams. The results of the degradation in vitro showed that both HA and β TCP had significant inhibitory effects on the degradation of PDLLA, especially the HA. It is expected that the composite foams are of use as scaffolds for bone tissue engineering.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
2004年第2期174-177,共4页
Journal of Biomedical Engineering
