摘要
目的 :评价小剂量胺碘酮与培哚普利联合治疗阵发性心房颤动 (房颤 )的临床疗效。方法 :将 10 8例阵发性房颤随机分为胺碘酮组 (Ⅰ组 ,n =5 3 )和胺碘酮 +培哚普利组 (Ⅱ组 ,n =5 5 ) ,治疗随访时间为 2年 ,研究终点为房颤发作。计算两组治疗后 3、6、9、12、18和 2 4个月的窦性心律维持率和治疗前、治疗后 6、12、18个月的左心房内径。结果 :两组治疗前和治疗后 6、12个月间左心房内径无差别 ,18个月后有显著性差异 (P <0 0 5 ) ;治疗后第 3、6、9个月 ,Ⅰ组窦性心律的维持率低于Ⅱ组 ,但无显著性差异 ,而治疗 12个月后 ,两组间有显著性差异 (P <0 0 5～ 0 0 2 5 ) ,治疗结束时Ⅰ组的窦性心律维持率为 61 2 2 % ,Ⅱ组为 82 3 5 %。结论 :胺碘酮与培哚普利联合治疗阵发性房颤维持窦性心律的疗效优于单用胺碘酮 ,并能延缓左心房的扩大。
Objective:To assess the curative effect of the combination of perindopril and low-dose amiodarone in patients with paroxysmal atrial fibrillation. Methods:One hundred patients with paroxysmal atrial fibrillation(PAF) were randomly divided into two groups:group Ⅰ (amiodarone group).and group Ⅱ(amiodarone plus perindopril group).The treatment lasted for two years.The left atrial diameter(LAD) was measured before and at the 6th,12th,and 18th months after treatment.The endpoint was the first recurrence of AF. Results:The difference of LAD was not significant between the two groups before and at the 6th and 12th months after treatment.At the 18th months after treatment,LAD in groupⅠwas significantly enlarged compared with that in groupⅡ (37.91±1.35 mm vs 36.11±1.35 mm,p<0.05).Themaintenance rate of sinus rhythm in groupⅠwas lower,but not significant than in groupⅡat the 3th,6th,9th months.However,it had significant difference at 12 months (p<0.05—<0.025),at the 24th months after treatment,the maintenance rate of sinus rhythm was 61.22% in groupⅠand 82.35% in groupⅡ(p<0.025 for both ). Conclusion:The combination of perindopril and amiodarone is more effective than amiodarone alone for sinus rhythm maintenance.Angiotensin converting enzyme inhibitors may delay the enlargement of the left atrium and reduce the recurrence rate of PAF.
出处
《中国循环杂志》
CSCD
北大核心
2004年第1期19-21,共3页
Chinese Circulation Journal
