摘要
谷氨酰胺 (Gln)是人体含量最为丰富的氨基酸 ,在感染、外伤等重症状态下 ,Gln被大量消耗 ,出现相对缺乏的状态 ;同时 ,体内的抗氧化剂如谷胱甘肽含量明显降低。补充Gln能够增加肝谷胱甘肽的合成 ,提高抗氧化损伤的能力 ,保护肝组织。在肠外营养液中添加Gln可以增加肠道的能量供应和抗感染能力 ,减少细菌和内毒素移位对肝的影响 ;还可以促进高血糖素分泌 ,降低门静脉中胰岛素 /高血糖素比例 。
Glutamine(Gln) is the most abundant free amino acid in the circulation. However, Gln depletion is obviously increased in critically ill patients. The liver plays a key role in glutamine metabolism since it can either generate or consume Gln. A number of studies have demonstrated that administration of Gln can protect from liver damage during sepsis or chemotherapy. The mechanism may be that glutamine can be more efficiently transported across cell membranes for glutathione synthesis. Supplement of Gln to PN has been proven to maintain intestinal integrity and reduce bacterial translocation. As a gluconeogenic amino acid, Gln can decrease the portal insulin/glucagon ratio and prevent hepatic steatosis through stimulating glucagon secretion.
出处
《肠外与肠内营养》
CAS
2004年第2期108-111,共4页
Parenteral & Enteral Nutrition
