摘要
以前的实验证明,电针镇痛同时提高脑干5-羟色胺(5-HT)水平可能是通过5-HT能下行抑制起作用。大鼠给予对氯苯丙氨酸(PCPA)。
The relation between clectroacupuncture (EA)analgesia (A)and substance P (SP)level in the brain stem(BS) and lumbar sp(?)nal cord (LSC) of arthralgic rats was investigated. The rats were divided into three groups:1)5.7-dihydroxytryptamine(5·7-DHT)+EA, 2)vehicle(V)+EA, and 3)5·7-DHT. All the animals were induced arthralgesia by injecting Freund's adjuvant 7 days after cisterna injection of 5·7-DHT or vehicle. The SP level in the BS and LSC was determined by RIA. The results indicated that in V+EA group the EA could prolong tail flick latency by 39.6%, but in other two groups did not. The SP level in LSC of V+EA group (179.1±11.5pmol/g) was higher than that in the 5·7-DHT+EA (135.9+9.3pmol/g)and 5·7-DHT (125.8±10.0 pmol/g) groups. It suggested that both EA and arthralgia could activate the descending 5-HTergic inhibitory system to inhibit the release of SP in LSC, When the 5-HTergic system was destroyedby 5·7-DHT, the EAA was attenuated, and the SP level in LSC was lowered due to its release was decreased by EA and arthralgia.
出处
《针刺研究》
CAS
CSCD
1992年第3期183-185,共3页
Acupuncture Research
