摘要
目的 研究补充大剂量维生素C、维生素E对 2型糖尿病患者血清可溶性血管细胞粘附分子(sVCAM) 1水平的影响。方法 用ELISA法测定 2型糖尿病患者补充维生素前后血清sVCAM 1水平并分析其与肿瘤坏死因子α(TNF α)、内皮素 (ET)、HbA1c、空腹血糖、甘油三酯、胆固醇、胰岛素 (IRI)的关系。结果 2型糖尿病患者补充大剂量维生素C、维生素E后sVCAM 1、TNF α、ET水平下降 ,联合服用组下降更明显 ;sVCAM 1与TNF α、ET及HbA1c呈正相关。结论 大剂量维生素C、维生素E能够降低 2型糖尿病患者血清sVCAM 1的水平并具有协同作用 ,其机制可能与维生素C、维生素E的抗氧化、抗糖化作用致HbA1c生成减少、TNF α、ET水平减低有关。
Objective To study the effect of high vitamin C and vitamin E intake on serum level of soluble vascular cell adhesion molecules (sVCAM)-1 in type 2 diabetic patients. Methods Serum level of sVCAM-1 was measured by ELISA before and after vitamin supplement in 60 patients with type 2 diabetes. The correlations between sVCAM-1 and tumor necrosis factor (TNF)-α, endothelin (ET), HbA 1c , fasting blood glucose, triglyceride, total cholesterol, immunoreactive insulin were determined respectively, and 20 patients served as controls. Results Serum level of sVCAM-1 decreased after high vitamin C and vitamin E intake, especially in the combined vitamins group; there were positive correlations between sVCAM-1 and TNF-α, ET, HbA 1c respectively. Conclusion High vitamin C and vitamin E intake can decrease the serum level of sVCAM-1 in type 2 diabetic patients and show synergistic action, the mechanism is probably due to their antioxidation and antiglycosylation, resulting in lowered levels of HbA 1c , TNFα and ET.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2003年第2期119-121,共3页
Chinese Journal of Endocrinology and Metabolism
