摘要
观察含羟基喜树碱冻干粉剂(拓僖)方案与含羟基喜树碱水剂方案治疗大肠癌的疗效及不良反应。方法:以含拓僖方案(A组)(拓僖+5-氟脲嘧啶+甲酰四氢叶酸钙+顺铂)作为治疗大肠癌的化疗方案与同期含羟基喜树碱水剂方案(羟基喜树碱+5-氟脲嘧啶+甲酰四氢叶酸钙+顺铂)比较,其中含羟基喜树碱水剂方案分为两组剂量,第1组(B组)羟基喜树碱为10mg/d,第2组(C组)羟基喜树碱为16mg/d。观察各组治疗方案治疗效果及不良反应。结果:各组的治疗效果无显著性差异(P>0.05)。含羟基喜树碱水剂方案16mg/d组血液系统不良反应大,有显著性差异(P<0.05)。结论:拓僖可作为羟基喜树碱水剂的替代剂型应用于治疗大肠癌的联合化疗。
Objective:To evaluate the effects and toxic-side reactions in the colorectal carcinoma Patients who used the Hydroxycamptothecin For Injection(TUOXI)regimen or Hydroxy-camptothecin Injection regimen.Methods:The colorectal carcinoma patients were divided into two groups;Hydroxycamptothecin For Injection(TUOXI)group(TUOXI+5-FU+CF+DDP)and the Hydroxycamptothecin Injection group(HCPT+5-FU+CF+DDP).The latter group was divided into two group by dose,the dose of one group is10mg /d and another group is16mg /d.After the analysis of data,comparing the efficacy and toxic-side reactions of Hydroxycamptothecin For Injection group and Hydroxycamptothecin Injection group.Results:The effective rate of the both groups have not any significant difference(P>0.05).Myelosuppression of the16mg /d group were more serious than the other groups,and they had a significant difference(P<0.05).Conclusions:In combinated chemotherapy Hydroxycamptothecin For Injection(TUOXI)can replace Hydroxy-camptothecin Injection in the treatment of colorectal carcinoma.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2003年第8期585-587,共3页
Chinese Journal of Clinical Oncology
关键词
恶性肿瘤
化疗
羟基喜树碱冻干粉剂(拓僖)
Malignant tumor Chemotherapy Hydroxycamptothecin for Injection(TUOXI)
