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溶血磷脂酸在早期缺血性脑血管病发生中的作用及对疗效和预后的评估价值 被引量:10

Application of plasma lysophosphatidic acid in patients with early cerebral ischemic attack and evaluation of therapeutic effect and prognosis.
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摘要 溶血磷脂(lysophospholipid,LPL)是当前脂类研究的一个热点。由于它们的命名是根据它们化学结构和物化性质,因此有一系列磷脂可以被称为溶血磷脂。但实际上多数情况下主要指那些具有生长因子样作用的这部分磷脂。其中是重要的是溶血磷脂酸(lysophosphatidieacid,LPA)和神经鞘氨醇1磷酸。近年来的研究发现:溶血磷脂酸在脑血管病的发生中起着重要作用。主要表现为以下两个方面:一个是诊断学方面,由于溶血磷脂酸的释放特点,它有可能作为一个分子标记物,标示血小板等细胞的活化,预警血栓形成的危险性;另一个是病理机制方面,溶血磷脂酸具有致动脉硬化和血栓形成的作用。它可能被应用在治疗和预防上,即利用它的受体拮抗(或促进)剂进行相应的干预。
出处 《中国临床康复》 CSCD 2004年第4期710-711,共2页 Chinese Journal of Clinical Rehabilitation
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