摘要
血管内皮生长因子(vascular endothelial growth factor, VEGF),又名血管通透性因子(vascular per-meability factor, VPF)是重要的血管生成正性调节因子,是目前抗癌治疗的研究靶点之一。现已发现的VEGF家族成员包括VEGF-A、VEGF-B、VEGF-C、VEGF-D、VEGF-E和胎盘生长因子(placenta growth factor,PLGF)。VEGF的受体有VEGFR-1(flt-1)、 VEGFR-2(flk-1/KDR)、 VEGFR-3(flt-4)、 neuropilin(NPR1/NPR2)。该家族的成员可以选择性地增强血管和/或淋巴管内皮细胞的有丝分裂,刺激内皮细胞增殖并促进血管生成,提高血管特别是微小血管的通透性,使血浆大分子外渗沉积在血管外的基质中,促进新生毛细血管网的建立,为肿瘤细胞的生长提供营养等。作者对VEGF家族成员及其受体的理化特征、VEGF与肿瘤的关系、VEGF抑制剂的研制作一综述。
Vascular endothelial growth factor (VEGF) also named vascular permeability factor (VPF), is an impor-tant positive regulator for angiogenesis. This is one target of the anticancer research. Discovered members ofVEGF family include: VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E and placenta growth factor (PLGF). Recep-tors of VEGF are VEGFR-1(flt-1), VEGFR-2(flk-1/KDR), VEGFR-3(flt-4) and neuropilin(NPR1/NPR2). Mem-bers of this family can selectively promote mitosis of vascular endotheial cells or lymphatic endothelial cells, stimu-late endothelial cells to proliferate and induce angiogenesis. They also enhance the permeability of microvessels,help to establish capillary vessels net. This article mainly reviewed the structures, functional characteristics, rela-tionship between VEGF and its inhibitors and tumor angiogenesis.
出处
《生命科学》
CSCD
2004年第1期19-23,共5页
Chinese Bulletin of Life Sciences
关键词
血管内皮生长因子
血管内皮生长因子受体
肿瘤血管生成
vascular endothelial growth factor
vascular endothelial growth factors receptors
angiogenesis
