摘要
iv莲心碱(Lien)3mg/kg可一过性地抑制麻醉或毁脊髓大鼠血流动力学诸指标,对麻醉大鼠LVP,+dp/dt_(max)及SAP的抑制较奎尼丁(Qui)3mg/kg为强;Lien 1～30 mg/kg可依量性地产生上述效应,12mg/kg的Lien和Qui分别使LVP,+dp/dt_(max),SAP下降33％,37％,29％和9％,12％,9％,而二者对其它血流动力学参数的抑制程度却相近。Lien 12 mg/kg对血流动力学诸指标的抑制强度与维拉帕米(Ver)1 mg/kg相似。Lien 1～100μmol/L可浓度依赖性地抑制左房收缩力和右房频率。提示其对血流动力学影响的特性与Ver更相似而与Qui有别。
Liensinine(Lien), an alkaloid extracted from the green seed embryo of Nelumbo nucifera Gaertn, has been shown to have anti-arrhythmic action, its mechanism may be related toblockade of Ca^(2+),Na^+ influx. Lien 3 mg/kg iv may temporarily inhibit all parameters of haemo-dynamics in anesthetized or pithed rats. The inhibitory effects on LVP, +dp/dt_(max), and SAP in anes-thetized rats are slightly stronger than those of quinidine(Oui) 3 mg/kg. Lien 1～30 mg/kg dose-de-pendently produced these actions. Lien and Qui 12 mg/kg lowered LVP, +dp/dt_(max), and SAP by33%, 37%, 29% and 9%, 12%, 9% respectively. While both of them inhibited the other param-eters of haemodynamics with nearly equal degrees. The degrees of inhibitory effect of Lien 12 mg/kgon all haemodynamic parameters nearly corresponded to these of verapamil 1 mg/kg. Lien 1～100μmol/L reduced the contractile force of isolated left atria and the spontaneously beating rate of isolatedright atria of rabbits in concentration-dependent manner. Thes esults indicate that the properties of the effect of Lien on haemodynamics may be similar to those of verapamil and different from those ofQui.
出处
《药学学报》
CAS
CSCD
北大核心
1992年第12期881-885,共5页
Acta Pharmaceutica Sinica
