摘要
采用超临界流体色谱法(SFC)分别测定了不同产地的怀牛膝药材及三种含怀牛膝的制剂中齐墩果酸的含量。方法简单、快速。不需经特殊的纯化处理。各产地药材齐墩果酸含量波动较小(1.75～2.19％,x±SD=1.94±0.17％),可以作为药材与制剂质量评价的指标,药材的加样回收率为97.42％(n=18,RSD=2.80％);制剂天麻丸的加样回收率为94.82％(n=9,RSD=2.51％)。
Capillary SFC was used for the determination of oleanolic acid in Achyranthes bidenta-ta BLume and its preparations Tianmawan, Jinguishenqiwan and Hechedazaowan. The amount ofoleanolic acid in the root of Achyranthes bidentata BLume was 1. 75～2. 19% (x±SD=1.94±0. 17%). The limit of detection was 9. 605×10^(-11) g. The method is highly sensitive, accurate, repro-ducible, simple, rapid and specific, so, it can be extensively used for the determination of other prepa-rations and crude herbs.
出处
《药学学报》
CAS
CSCD
北大核心
1992年第9期690-694,共5页
Acta Pharmaceutica Sinica
基金
国家自然基金
关键词
牛膝
齐墩果酸
天麻丸
SFC
Supercritical fluid chromatography
Achyranthes bidentata BL.
Oleanolic acid
