摘要
自六十年代初期发现羧乙基锗倍半氧化物(Ge—132)广泛的生物活性以来,已有许多相应的有机锗化合物被发现,在抗肿瘤活性方面,因有毒性较低、抗瘤谱广等一系列优点而引起人们广泛的兴趣,但由于活性较低影响了应用及发展,据文献报道。
Someβ- germanyl- α- amino acid derivatives were prepared from thereaction of HGeCl_3 with substituted oxazolines. The compositions of the above com-pounds were studied using IR, element analysis and so on. Experimental results were asfollows: for 1- substituted- 2-amino- 2-carboxyethylgermanium susquioxide (sush asⅢb), the po LD_(50) for mice was found to be above 10 g/kg. When given ip, a maximuminhibition of 50% of the growth of S180 was obtained for Ⅲb, whereas an inhibition of42% was achieved for 5- Fu under the same experimental condition.
出处
《药学学报》
CAS
CSCD
北大核心
1992年第2期150-152,共3页
Acta Pharmaceutica Sinica
关键词
氨基酸衍生物
锗化合物
抗肿瘤作用
Germanyl aminoacid derivative
Organogermanium sesquioxide
Antitumor activity
