摘要
目的 通过研究曲美他嗪对冠心病校正QT间期离散度 (QTcd)的影响 ,探讨曲美他嗪治疗对冠心病缺血心肌的保护作用。方法 72例冠心病患者随机分为曲美他嗪治疗组和非曲美他嗪治疗组 ,观察其治疗前后QTcmax ,QTcmin和QTcd的变化。另设正常人 2 0例作对照组。结果 冠心病患者QTcmax和QTcd较正常人增大 ,与治疗前相比 ,两组冠心病患者治疗后QTcmax和QTcd均有显著减少 (P <0 .0 1)。其中以曲美他嗪治疗组更明显。同时 ,两组间比较 ,治疗后QTcmax和QTcd有显著差异 (P <0 .0 1) ,曲美他嗪治疗组减少更明显。结论 冠心病患者QTcmax和QTcd较正常人增大 ,曲美他嗪通过缩小QTcmax而减少冠心病患者QTcd。
Objective: To investigate the effect of trimetazidine on the corrected QT dispersion (QTcd) in patients with coronary heart disease.Methods:72 patients were divided into 2 groups at random: trimetazidine treatment group (conventional treatment + trimetazidine) and conventional treatment group. Normal group(n=20) was regarded as control. The changes of QTcmax, QTcmin, QTcd were measured before and after treatment.Results:QTcmax and QTcd increased significantly in patients with coronary heart disease compared with those of the control. Both QTcmax, QTcd were decreased significantly in two groups after 7 days of treatment (P<0.01). But they decreased more obviously in trimetazidine treatment group than those in conventional group. There were significant differences in QTcmax and QTcd of two groups after treatment (P<0.01). QTcmax and QTcd decreased more significantly in trimetazidine treatment group than those in conventional group(P<0.01). Conclusions:QTcmax and QTcd increased apparently in patients with coronary heart disease. Trimetazidine can signifcantly decrease the QTcd of patients with coronary heart disease by shortening QTcmax.
出处
《中国现代医学杂志》
CAS
CSCD
2004年第3期94-96,共3页
China Journal of Modern Medicine
关键词
曲美他嗪
冠心病
QT离散度
校正
Trimetazidine
Coronary heart disease
QT dispersion(QTd)
Correct
